Passalacqua Giovanni, Mincarini Marcello, Colombo Daniele, Troisi Giuseppe, Ferrari Marta, Bagnasco Diego, Balbi Francesco, Riccio Annamaria, Canonica Giorgio Walter
Allergy and Respiratory Diseases, IRCCS San Martino-IST-University of Genoa, Italy.
Allergy and Respiratory Diseases, IRCCS San Martino-IST-University of Genoa, Italy.
Pulm Pharmacol Ther. 2017 Aug;45:95-100. doi: 10.1016/j.pupt.2017.05.007. Epub 2017 May 10.
The recent advances in the knowledge of immunological aspects of many pulmonary diseases, allowed to identify cells, biological functions, cytokines, and receptors that are preferentially involved in each disease. This is the case of asthma, where IL-13 (together with IL-4) is recognized as a central mediator. The role of IL-13 is strictly related, via complex signaling pathways, to eosinophil recruitment and activation, to mucus secretion, periostin generation and to fibrogenic processes (which are part of the remodeling process). These peculiar roles of IL-13 have suggested the hypothesis of its role in Idiopathic Pulmonary Fibrosis, and consequently of its antagonists in the treatment of such disease. We review herein the immunological roles of IL-13 in asthma and IPF, and the currently ongoing attempts to treat IPF by IL-13 antagonism strategies.
近年来，在许多肺部疾病免疫方面的知识取得了进展，这使得人们能够识别出在每种疾病中优先涉及的细胞、生物学功能、细胞因子和受体。哮喘就是这样的情况，其中白细胞介素-13（与白细胞介素-4一起）被认为是一种核心介质。白细胞介素-13的作用通过复杂的信号通路与嗜酸性粒细胞的募集和激活、黏液分泌、骨膜蛋白的产生以及纤维化过程（这是重塑过程的一部分）密切相关。白细胞介素-13的这些特殊作用提示了其在特发性肺纤维化中作用的假说，以及其拮抗剂在治疗该疾病中的作用。我们在此综述白细胞介素-13在哮喘和特发性肺纤维化中的免疫作用，以及目前通过白细胞介素-13拮抗策略治疗特发性肺纤维化的尝试。
