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2
High Concordance Between Mental Stress-Induced and Adenosine-Induced Myocardial Ischemia Assessed Using SPECT in Heart Failure Patients: Hemodynamic and Biomarker Correlates.心力衰竭患者中使用单光子发射计算机断层扫描(SPECT)评估的精神应激诱导的心肌缺血与腺苷诱导的心肌缺血之间的高度一致性:血流动力学和生物标志物相关性
J Nucl Med. 2015 Oct;56(10):1527-33. doi: 10.2967/jnumed.115.157990. Epub 2015 Jul 23.
3
Prognostic significance of active and modified forms of endothelin 1 in patients with heart failure with reduced ejection fraction.射血分数降低的心力衰竭患者中内皮素1活性形式和修饰形式的预后意义。
Clin Biochem. 2015 Mar;48(4-5):292-6. doi: 10.1016/j.clinbiochem.2014.12.012. Epub 2014 Dec 23.
4
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BMC Pulm Med. 2014 Aug 11;14:136. doi: 10.1186/1471-2466-14-136.
5
Heart failure in hospitalized patients with diabetic foot ulcers: clinical characteristics and their relationship with prognosis.住院的糖尿病足溃疡患者的心衰:临床特征及其与预后的关系。
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Peripheral arterial disease and chronic heart failure: a dangerous mix.外周动脉疾病和慢性心力衰竭:危险的组合。
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Six minute walk test predicts long-term all-cause mortality and heart failure rehospitalization in African-American patients hospitalized with acute decompensated heart failure.六分钟步行试验可预测因急性失代偿性心力衰竭住院的非裔美国患者的长期全因死亡率和心力衰竭再住院情况。
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8
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9
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一种新的适用于心力衰竭患者功能状态的临床测量方法:60英尺步行测试。

A New Clinically Applicable Measure of Functional Status in Patients With Heart Failure: The 60-Foot Walk Test.

作者信息

Harris Kristie M, Krantz David S, Kop Willem J, Marshall Joanne, Robinson Shawn W, Marshall Jennifer M, Gottlieb Stephen S

机构信息

Department of Psychology, The Ohio State University, Columbus, Ohio.

Department of Medical and Clinical Psychology, Uniformed Services University of the Health Sciences, Bethesda, Maryland.

出版信息

JACC Heart Fail. 2017 Jun;5(6):411-420. doi: 10.1016/j.jchf.2017.02.005. Epub 2017 May 10.

DOI:10.1016/j.jchf.2017.02.005
PMID:28501523
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5457315/
Abstract

OBJECTIVES

This study reports the development and predictive value of the 60-foot walk test (60ftWT), a brief functional status measure for patients with heart failure (HF). The goal was to develop a test suitable for clinical settings and appropriate for patients with walking impairments.

BACKGROUND

The 6-min walk test (6MWT) has considerable predictive value, but requires a long walking course and has limited utility in patients with mobility-related comorbidities. A shorter, more clinically practical test is therefore needed.

METHODS

A total of 144 patients (age 57.4 ± 11.4 years; 111 males) with symptomatic HF received baseline assessments using the 60ftWT, 6MWT, and self-reported symptom and health status. Patients were tested 3 months later to determine stability of assessments. HF hospitalizations or death from any cause were recorded for 3.5 years following baseline.

RESULTS

Median 60ftWT completion time was 26 s (interquartile range: 22 to 31 s). Longer 60ftWT time was associated with shorter 6MWT distance (r = -0.75; p < 0.001), and with higher symptom severity at baseline (r = -0.40; p < 0.001). Longer 60ftWT times also predicted increases in 6MWT and symptoms from baseline to 3 months (p < 0.01). Both WTs predicted long-term clinical outcomes, with patients taking longer than 31 s to complete the 60ftWT at greatest risk for HF hospitalization or death (hazard ratio: 2.13; 95% confidence interval: 1.18 to 3.84; p = 0.01).

CONCLUSIONS

The 60ftWT is an easily administered functional status measure that predicts adverse events, symptoms, and health status. It has the potential for considerable clinical utility to help identify patients at risk for future events and to calibrate treatments designed to improve functional status and quality of life.

摘要

目的

本研究报告了60英尺步行试验(60ftWT)的开发及其预测价值,这是一种针对心力衰竭(HF)患者的简短功能状态测量方法。目标是开发一种适用于临床环境且适合有步行障碍患者的测试。

背景

6分钟步行试验(6MWT)具有相当大的预测价值,但需要较长的步行路程,并且在患有与活动相关合并症的患者中效用有限。因此,需要一种更短、更具临床实用性的测试。

方法

共有144例有症状HF患者(年龄57.4±11.4岁;男性111例)接受了使用60ftWT、6MWT以及自我报告的症状和健康状况的基线评估。3个月后对患者进行测试以确定评估的稳定性。在基线后3.5年记录HF住院或任何原因导致的死亡情况。

结果

60ftWT完成时间的中位数为26秒(四分位间距:22至31秒)。60ftWT时间越长,与6MWT距离越短相关(r = -0.75;p < 0.001),并且与基线时更高的症状严重程度相关(r = -0.40;p < 0.001)。60ftWT时间越长还预测了从基线到3个月时6MWT和症状的增加(p < 0.01)。两种步行试验均能预测长期临床结局,60ftWT完成时间超过31秒的患者发生HF住院或死亡的风险最高(风险比:2.13;95%置信区间:1.18至3.84;p = 0.01)。

结论

60ftWT是一种易于实施的功能状态测量方法,可预测不良事件、症状和健康状况。它具有相当大的临床实用潜力,有助于识别未来事件风险患者,并校准旨在改善功能状态和生活质量的治疗方法。