Lietzau Grazyna, Darsalia Vladimer, Pintana Hiranya, Östenson Claes-Göran, Nyström Thomas, Fisahn André, Patrone Cesare
Department of Clinical Science and Education, Södersjukhuset, Internal Medicine, Karolinska Institutet, Stockholm, Sweden; Medical University of Gdansk, Department of Anatomy and Neurobiology, Gdansk, Poland.
Department of Clinical Science and Education, Södersjukhuset, Internal Medicine, Karolinska Institutet, Stockholm, Sweden.
Psychoneuroendocrinology. 2017 Aug;82:46-50. doi: 10.1016/j.psyneuen.2017.04.012. Epub 2017 Apr 27.
Type 2 diabetes (T2D) has been associated with cognitive decline, dementia and Alzheimer's disease (AD). Remarkably, the pathophysiological mechanisms behind this are still mostly unknown. Cognition and memory formation are associated with gamma oscillations in hippocampal neuronal networks and fast-spiking, parvalbumin-expressing interneurons (PV+ IN) play a key role in these processes.
2型糖尿病（T2D）与认知能力下降、痴呆症和阿尔茨海默病（AD）有关。值得注意的是，其背后的病理生理机制大多仍不为人知。认知和记忆形成与海马神经元网络中的γ振荡有关，快速放电、表达小白蛋白的中间神经元（PV+IN）在这些过程中起关键作用。
