Branch Clinical Research. Laboratory of Molecular Neurobiology and Neurochemistry of Addiction, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City, Mexico.
Branch Clinical Research. Laboratory of Molecular Neurobiology and Neurochemistry of Addiction, National Institute of Psychiatry Ramón de la Fuente Muñiz, Mexico City, Mexico.
Psychiatry Res. 2017 Aug;254:301-310. doi: 10.1016/j.psychres.2017.05.006. Epub 2017 May 5.
Relapse to cocaine use is a major problem in the clinical treatment of cocaine dependence. Antidepressant medications have been studied as potential therapeutic drugs to relieve a cocaine dependence disorder. Mirtazapine is an antidepressant implicated in reducing behavioral alterations induced by drugs of abuse. We have reported elsewhere that 30mg/kg mirtazapine administered for 30 days during cocaine extinction significantly attenuated the induction and expression of cocaine-induced locomotor sensitization and decreased the duration of the cocaine-induced locomotor effect. This study focused on exploring whether different mirtazapine dosing regimens could optimize and/or improve the effect of 30mg/kg mirtazapine administered for 30 days on cocaine-induced locomotor activity during the expression phase of behavioral sensitization. Our study revealed that the daily dosing regimen with a fixed dose of mirtazapine (30mg/kg ip) over 60 days improved the decrease in cocaine-induced locomotor activity and behavioral sensitization obtained by dosing of 30mg mirtazapine for 30 days. In addition, it showed that a dosing regimen of 30mg/Kg mirtazapine for 30 days managed to reduce cocaine toxicity. These results suggested that dosage of mirtazapine for 30 consecutive days may be an effective therapy.
可卡因使用的复发是可卡因依赖临床治疗中的一个主要问题。抗抑郁药物已被研究为潜在的治疗药物，以缓解可卡因依赖障碍。米氮平是一种与减少滥用药物引起的行为改变有关的抗抑郁药。我们在其他地方报告说，在可卡因消退期间给予 30mg/kg 米氮平 30 天，可显著减弱可卡因诱导的运动敏化的诱导和表达，并减少可卡因诱导的运动效应的持续时间。本研究集中探讨了不同米氮平剂量方案是否可以优化和/或改善在行为敏化表达阶段给予 30mg/kg 米氮平 30 天对可卡因诱导的运动活性的影响。我们的研究表明，60 天内每天给予固定剂量米氮平（30mg/kg ip）的剂量方案改善了 30mg 米氮平 30 天剂量方案获得的可卡因诱导的运动活性和行为敏化的降低。此外，它表明 30mg/kg 米氮平 30 天的剂量方案可降低可卡因的毒性。这些结果表明，连续 30 天给予米氮平可能是一种有效的治疗方法。
