Salazar-Juárez Alberto, Barbosa-Méndez Susana, Jurado Noe, Hernández-Miramontes Ricardo, Leff Philippe, Antón Benito
Subdirección de investigaciones Clínicas, Laboratorio de Neurobiología Molecular y Neuroquímica de las Adicciones, Instituto Nacional de Psiquiatría, México DF 14370, Mexico.
Subdirección de investigaciones Clínicas, Laboratorio de Neurobiología Molecular y Neuroquímica de las Adicciones, Instituto Nacional de Psiquiatría, México DF 14370, Mexico.
Prog Neuropsychopharmacol Biol Psychiatry. 2016 Jul 4;68:15-24. doi: 10.1016/j.pnpbp.2016.02.010. Epub 2016 Feb 26.
Cocaine abuse is a major health problem worldwide. Treatment based on both 5-HT2A/C and 5-HT3 receptor antagonists attenuate not only the effects of cocaine abuse but also the incentive/motivational effect related to cocaine-paired cues. Mirtazapine, an antagonist of postsynaptic α2-adrenergic, 5-HT2A/C and 5HT3 receptors and inverse agonist of the 5-HT2C receptor, has been shown to effectively modify, at the preclinical and clinical levels, various behavioral alterations induced by drugs abuse. Therefore, it is important to assess whether chronic dosing of mirtazapine alters locomotor effects of cocaine as well as induction and expression of cocaine sensitization. Our results reveal that a daily mirtazapine regimen administered for 30days effectively induces a significant attenuation of cocaine-dependent locomotor activity and as well as the induction and expression of behavioral sensitization. These results suggest that mirtazapine may be used as a potentially effective therapy to attenuate induction and expression of cocaine-induced locomotor sensitization.
可卡因滥用是一个全球性的重大健康问题。基于5-HT2A/C和5-HT3受体拮抗剂的治疗不仅能减轻可卡因滥用的影响，还能减轻与可卡因配对线索相关的动机/激励效应。米氮平是一种突触后α2-肾上腺素能、5-HT2A/C和5HT3受体的拮抗剂以及5-HT2C受体的反向激动剂，已被证明在临床前和临床水平上能有效改变药物滥用引起的各种行为改变。因此，评估米氮平的长期给药是否会改变可卡因的运动效应以及可卡因敏化的诱导和表达非常重要。我们的结果表明，连续30天每日服用米氮平可有效诱导可卡因依赖性运动活动以及行为敏化的诱导和表达显著减弱。这些结果表明，米氮平可能作为一种潜在有效的疗法来减轻可卡因诱导的运动敏化的诱导和表达。
