Freelance Researcher, Marburg, Germany.
Life Science Team, Bech-Bruun Law Firm, Copenhagen, Denmark.
Acta Psychiatr Scand. 2017 Jul;136(1):37-51. doi: 10.1111/acps.12742. Epub 2017 May 14.
There is some evidence that clozapine is significantly underutilised. Also, clozapine use is thought to vary by country, but so far no international study has assessed trends in clozapine prescribing. Therefore, this study aimed to assess clozapine use trends on an international scale, using standardised criteria for data analysis.
A repeated cross-sectional design was applied to data extracts (2005-2014) from 17 countries worldwide.
In 2014, overall clozapine use prevalence was greatest in Finland (189.2/100 000 persons) and in New Zealand (116.3/100 000), and lowest in the Japanese cohort (0.6/100 000), and in the privately insured US cohort (14.0/100 000). From 2005 to 2014, clozapine use increased in almost all studied countries (relative increase: 7.8-197.2%). In most countries, clozapine use was highest in 40-59-year-olds (range: 0.6/100 000 (Japan) to 344.8/100 000 (Finland)). In youths (10-19 years), clozapine use was highest in Finland (24.7/100 000) and in the publicly insured US cohort (15.5/100 000).
While clozapine use has increased in most studied countries over recent years, clozapine is still underutilised in many countries, with clozapine utilisation patterns differing significantly between countries. Future research should address the implementation of interventions designed to facilitate increased clozapine utilisation.
有证据表明氯氮平的应用明显不足。此外，氯氮平的应用被认为因国家而异，但迄今为止，尚无国际研究评估氯氮平处方的趋势。因此，本研究旨在采用标准化数据分析标准，评估国际范围内氯氮平的应用趋势。
采用重复横断面设计，对来自全球 17 个国家的数据（2005-2014 年）进行提取。
2014 年，芬兰（189.2/100000 人）和新西兰（116.3/100000 人）的氯氮平总体使用率最高，日本队列（0.6/100000 人）和美国私人保险队列（14.0/100000 人）的氯氮平使用率最低。2005 年至 2014 年，几乎所有研究国家的氯氮平使用率均有所增加（相对增长率：7.8-197.2%）。在大多数国家，40-59 岁人群的氯氮平使用率最高（范围：0.6/100000（日本）至 344.8/100000（芬兰））。在青少年（10-19 岁）中，芬兰（24.7/100000）和美国公共保险队列（15.5/100000）的氯氮平使用率最高。
近年来，大多数研究国家的氯氮平使用率有所增加，但在许多国家，氯氮平的应用仍不足，各国的氯氮平应用模式存在显著差异。未来的研究应针对实施旨在促进氯氮平应用增加的干预措施。
