Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Medical Genetics Research Center, Student Research Committee, Department of Medical Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Cell Oncol (Dordr). 2019 Oct;42(5):591-608. doi: 10.1007/s13402-019-00453-z. Epub 2019 May 29.
Tumor-associated macrophages (TAMs) are known to play important roles in the initiation and progression of human cancers, as well as in angiogenesis. TAMs are considered as main components of the tumor microenvironment. Targeting TAMs may serve as a therapeutic strategy for the treatment of cancer. In this review, the signaling pathways, origin, function, polarization and clinical application of TAMs are discussed. The role of TAMs in tumor initiation, progression, angiogenesis, invasion and metastasis are also emphasized. In addition, a variety of clinical and pre-clinical approaches to target TAMs are discussed.
Clinical therapeutic approaches that show most promise include blocking the extravasation of TAMs along with using TAMs as diagnostic biomarkers for cancer progression. The targeting of TAMs in a variety of clinical settings appears to be a promising strategy for decreasing metastasis formation and for improving patient outcome.
肿瘤相关巨噬细胞（TAMs）在人类癌症的发生和发展以及血管生成中起着重要作用。TAMs 被认为是肿瘤微环境的主要组成部分。针对 TAMs 可能是治疗癌症的一种治疗策略。在这篇综述中，讨论了 TAMs 的信号通路、起源、功能、极化和临床应用。还强调了 TAMs 在肿瘤起始、进展、血管生成、侵袭和转移中的作用。此外，还讨论了各种针对 TAMs 的临床和临床前方法。
最有希望的临床治疗方法包括阻止 TAMs 的渗出以及将 TAMs 用作癌症进展的诊断生物标志物。在各种临床环境中靶向 TAMs 似乎是减少转移形成和改善患者预后的一种有前途的策略。
