[Intracellular mechanisms of the effect of cytochrome C on various areas of the myocardium during the dynamic development of an experimental infarct].

The effectiveness of the drug was shown to depend on the number of reversibly damaged cells. The intracellular mechanisms of cytochrome C effect are thought to be related to both the possibility of its permeation through the changed cell membrane of a cardiomyocyte and the action of the drug directly on sarcolemma. Predominantly in the early periods of the study one could note a marked preservation of the ultrastructure of cardiomyocytes, a decrease of degradation of adenine nucleotides and cytochrome aa3 and in the long run limitation of the sizes of necrosis zone.