Lou Z C, Lou Z H
Department of Otorhinolaryngology,Affiliated YiWu Hospital of Wenzhou Medical University,Zhejiang,China.
Department of Clinical Medicine,Xinxiang Medical University,Henan,China.
J Laryngol Otol. 2017 Jul;131(7):564-571. doi: 10.1017/S0022215117001001. Epub 2017 May 15.
To review the history of moist therapy used to regenerate traumatic tympanic membrane perforations.
Literature review.
The literature on topical agents used to treat traumatic tympanic membrane perforations was reviewed, and the advantages and disadvantages of moist therapy were analysed.
A total of 76 studies were included in the analysis. Topical applications of certain agents (e.g. growth factors, Ofloxacin Otic Solution, and insulin solutions) to the moist edges of traumatic tympanic membrane perforations shortened closure times and improved closure rates.
Dry tympanic membrane perforation edges may be associated with crust formation and centrifugal migration, delaying perforation closure. On the contrary, moist edges inhibit necrosis at the perforation margins, stimulate proliferation of granulation tissue and aid eardrum healing. Thus, moist perforation margins upon topical application of solutions of appropriate agents aid the regeneration of traumatic tympanic membrane perforations.
回顾用于创伤性鼓膜穿孔再生的湿性疗法的历史。
文献综述。
回顾用于治疗创伤性鼓膜穿孔的局部用药文献，并分析湿性疗法的优缺点。
分析共纳入76项研究。将某些药物（如生长因子、氧氟沙星滴耳液和胰岛素溶液）局部应用于创伤性鼓膜穿孔的湿润边缘可缩短愈合时间并提高愈合率。
干燥的鼓膜穿孔边缘可能与结痂形成和离心迁移有关，从而延迟穿孔愈合。相反，湿润边缘可抑制穿孔边缘的坏死，刺激肉芽组织增殖并促进鼓膜愈合。因此，局部应用适当药物溶液使穿孔边缘保持湿润有助于创伤性鼓膜穿孔的再生。
