Gold Diane R, Adamkiewicz Gary, Arshad Syed Hasan, Celedón Juan C, Chapman Martin D, Chew Ginger L, Cook Donald N, Custovic Adnan, Gehring Ulrike, Gern James E, Johnson Christine C, Kennedy Suzanne, Koutrakis Petros, Leaderer Brian, Mitchell Herman, Litonjua Augusto A, Mueller Geoffrey A, O'Connor George T, Ownby Dennis, Phipatanakul Wanda, Persky Victoria, Perzanowski Matthew S, Ramsey Clare D, Salo Päivi M, Schwaninger Julie M, Sordillo Joanne E, Spira Avrum, Suglia Shakira F, Togias Alkis, Zeldin Darryl C, Matsui Elizabeth C
Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, Mass; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass.
Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Mass.
J Allergy Clin Immunol. 2017 Oct;140(4):933-949. doi: 10.1016/j.jaci.2017.04.024. Epub 2017 May 10.
Environmental exposures have been recognized as critical in the initiation and exacerbation of asthma, one of the most common chronic childhood diseases. The National Institute of Allergy and Infectious Diseases; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; and Merck Childhood Asthma Network sponsored a joint workshop to discuss the current state of science with respect to the indoor environment and its effects on the development and morbidity of childhood asthma. The workshop included US and international experts with backgrounds in allergy/allergens, immunology, asthma, environmental health, environmental exposures and pollutants, epidemiology, public health, and bioinformatics. Workshop participants provided new insights into the biologic properties of indoor exposures, indoor exposure assessment, and exposure reduction techniques. This informed a primary focus of the workshop: to critically review trials and research relevant to the prevention or control of asthma through environmental intervention. The participants identified important limitations and gaps in scientific methodologies and knowledge and proposed and prioritized areas for future research. The group reviewed socioeconomic and structural challenges to changing environmental exposure and offered recommendations for creative study design to overcome these challenges in trials to improve asthma management. The recommendations of this workshop can serve as guidance for future research in the study of the indoor environment and on environmental interventions as they pertain to the prevention and management of asthma and airway allergies.
环境暴露已被公认为是引发和加剧哮喘的关键因素，哮喘是儿童期最常见的慢性疾病之一。美国国立过敏与传染病研究所、国立环境卫生科学研究所、国立心肺血液研究所和默克儿童哮喘网络联合主办了一次研讨会，以讨论关于室内环境及其对儿童哮喘发展和发病率影响的科学现状。该研讨会邀请了来自美国和国际的专家，他们在过敏/过敏原、免疫学、哮喘、环境卫生、环境暴露与污染物、流行病学、公共卫生和生物信息学等领域具有背景。研讨会参与者对室内暴露的生物学特性、室内暴露评估和暴露减少技术提供了新的见解。这为研讨会的一个主要重点提供了信息：批判性地审查与通过环境干预预防或控制哮喘相关的试验和研究。参与者确定了科学方法和知识方面的重要局限性和差距，并提出了未来研究领域并确定其优先顺序。该小组审查了改变环境暴露的社会经济和结构挑战，并为创新研究设计提出了建议，以便在改善哮喘管理的试验中克服这些挑战。本次研讨会的建议可为未来关于室内环境以及与哮喘和气道过敏的预防与管理相关的环境干预措施的研究提供指导。
