Simón-Arceo Karina, González-Trujano Ma Eva, Coffeen Ulises, Fernández-Mas Rodrigo, Mercado Francisco, Almanza Angélica, Contreras Bernardo, Jaimes Orlando, Pellicer Francisco
Laboratorio de Neurofisiología Integrativa, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México Xochimilco 101, San Lorenzo Huipulco, Tlalpan, CP 14370 Ciudad de México, México.
Laboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México Xochimilco 101, San Lorenzo Huipulco, Tlalpan, CP 14370 Ciudad de México, México.
J Ethnopharmacol. 2017 Jul 12;206:115-124. doi: 10.1016/j.jep.2017.05.016. Epub 2017 May 11.
Salvia divinorum is a medicinal plant traditionally used in hallucinogenic ethnopharmacological practices and for its analgesic and antinflammatory properties. Its active compounds include diterpenes known as salvinorins which act as potent κ opioid receptor agonists.
Given its effects in acute animal models of pain, as well as its antinflammatory attributes, we decided to investigate the analgesic effects of an SD extract in neuropathic (sciatic loose nerve ligature) and inflammatory (intra plantar carrageenan) pain models in rats. We also determined in this study the electrocorticographic changes to correlate similar hallucinogenic state and behavior as those produced in humans.
Mechanical and thermonociceptive responses, plantar test and von Frey assay, respectively, were measured in adult Wistar rats 30min, 3h and 24h after the intraperitoneal administration of saline or an hydroponic SD extract. We also evaluated carbamazepine and celecoxib, as gold reference drugs, to compare its antinociceptive effects.
Our results showed that administration of SD extract induced antialgesic effects in both neuropathic and inflammatory pain models. All those effects were blocked by nor-binaltorphimine (a Kappa opioid receptor antagonist). Moreover, it was observed an increase of the anterior power spectral density and a decrease in the posterior region as electrocorticographic changes.
The present investigation give evidence that SD is capable to reduce algesic response associated to neuropathic and inflammatory nociception. This study support therapeutic alternatives for a disabling health problem due to the long term pain with high impact on population and personal and social implications.
鼠尾草是一种药用植物，传统上用于致幻民族药理学实践，并因其镇痛和抗炎特性而被使用。其活性化合物包括被称为鼠尾草素的二萜类化合物，它们是强效的κ阿片受体激动剂。
鉴于其在急性动物疼痛模型中的作用以及抗炎特性，我们决定研究鼠尾草提取物在大鼠神经性（坐骨神经松结扎）和炎症性（足底注射角叉菜胶）疼痛模型中的镇痛作用。我们还在本研究中确定了脑电图变化，以关联与人类产生的类似致幻状态和行为。
在成年Wistar大鼠腹腔注射生理盐水或水培鼠尾草提取物后30分钟、3小时和24小时，分别测量机械性和热痛觉感受反应、足底试验和von Frey试验。我们还评估了作为金标准药物的卡马西平和塞来昔布，以比较它们的抗伤害感受作用。
我们的结果表明，给予鼠尾草提取物在神经性和炎症性疼痛模型中均诱导了镇痛作用。所有这些作用均被去甲丁丙诺啡（一种κ阿片受体拮抗剂）阻断。此外，观察到脑电图变化表现为前部功率谱密度增加和后部区域减少。
本研究提供了证据表明鼠尾草能够减轻与神经性和炎症性伤害感受相关的痛觉反应。这项研究支持了针对一种因长期疼痛而导致的致残性健康问题的治疗选择，这种疼痛对人群以及个人和社会都有重大影响。
