Freo Ulderico, Romualdi Patrizia, Kress Hans G
Anesthesiology and Intensive Medicine, Department of Medicine DIMED, University of Padua, 35100 Padua, Italy.
Department of Pharmacy and Biotechnology, Alma Mater Studiorum-University of Bologna, 40126, Bologna, Italy.
J Pain Res. 2019 May 16;12:1537-1551. doi: 10.2147/JPR.S190162. eCollection 2019.
Neuropathic pain (NP) is an enormous burden for patients, caregivers and society. NP is a pain state that may develop after injury of the peripheral or central nervous system because of a wide range of diseases and traumas. A NP symptom component can be found also in several types of chronic pain. Many NP patients are substantially disabled for years. Due to its chronicity, severity and unpredictability, NP is difficult to treat. Tapentadol is a central-acting oral analgesic with combined opioid and noradrenergic properties, which make it potentially suitable for a wide range of pain conditions, particularly whenever a NP component is present or cannot be excluded. In randomized controlled trials, tapentadol has proved to be effective in relieving NP in diabetic peripheral neuropathy and in chronic low back pain. In observational studies, tapentadol reduced NP in chemotherapy-induced peripheral neuropathies, blood and solid cancers, and the NP component in neck pain and Parkinson's disease. This narrative review aims to provide clinicians with a broad overview of tapentadol effects on NP.
神经病理性疼痛（NP）对患者、护理人员和社会来说是一个巨大的负担。NP是一种疼痛状态，由于多种疾病和创伤，可能在外周或中枢神经系统损伤后出现。在几种慢性疼痛类型中也可发现NP症状成分。许多NP患者多年来严重致残。由于其慢性、严重性和不可预测性，NP难以治疗。曲马多是一种具有阿片类和去甲肾上腺素能联合特性的中枢作用口服镇痛药，这使其可能适用于多种疼痛情况，特别是当存在或不能排除NP成分时。在随机对照试验中，曲马多已被证明可有效缓解糖尿病性周围神经病变和慢性下腰痛中的NP。在观察性研究中，曲马多可减轻化疗引起的周围神经病变、血液和实体癌中的NP，以及颈部疼痛和帕金森病中的NP成分。本叙述性综述旨在为临床医生提供曲马多对NP作用的广泛概述。
