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骨髓增生异常综合征合并骶前髓外造血及非典型MRI表现

Myelodysplastic Syndrome Developing Presacral Extramedullary Hematopoiesis with Atypical MRI Findings.

作者信息

Sawada Haruki, Higuchi Takakazu, Koyamada Ryosuke, Okada Sadamu

机构信息

Internal Medicine, St Luke's International Hospital, Japan.

Division of Hematology, St Luke's International Hospital, Japan.

出版信息

Intern Med. 2017;56(10):1213-1217. doi: 10.2169/internalmedicine.56.7421. Epub 2017 May 15.

Abstract

A 64-year-old woman was diagnosed to have refractory cytopenia with multilineage dysplasia (RCMD) including an increased number of sideroblasts in the bone marrow (BM). Computed tomography (CT) revealed a presacral mass which showed iso- or high-intensity signals according to T1-weighted and hypo-intensity signals on T2-weighted magnetic resonance imaging (MRI). CT-guided biopsy revealed the presence of hematopoietic tissue with features that correlated with the BM findings. While the formation of extramedullary hematopoiesis in the presacral area is rare, it is important to differentiate it from other parasacral tumors even though such differentiation is often difficult. This patient demonstrated atypical MRI signals possibly due to an increase in the cellular iron content of the erythroid precursors.

摘要

一名64岁女性被诊断为多系发育异常的难治性血细胞减少症(RCMD),骨髓(BM)中环形铁粒幼细胞数量增加。计算机断层扫描(CT)显示骶前有一肿块,在T1加权磁共振成像(MRI)上呈等信号或高信号,在T2加权上呈低信号。CT引导下活检显示存在造血组织,其特征与骨髓检查结果相关。虽然骶前区域髓外造血的形成很少见,但将其与其他骶旁肿瘤区分开来很重要,尽管这种区分往往很困难。该患者表现出非典型的MRI信号,可能是由于红系前体细胞内铁含量增加所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/93aa/5491819/b201ef0647dc/1349-7235-56-1213-g001.jpg

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