Callahan M F, Kirby R F, Johnson A K, Gruber K A
Department of Psychology, University of Iowa, Iowa City 52242.
J Auton Nerv Syst. 1988 Sep;24(1-2):179-82. doi: 10.1016/0165-1838(88)90146-4.
Peptides of the ACTH4-10/gamma 2-MSH3-9 class produce pressor and cardioaccelerator effects upon i.v. administration. These actions appear to be mediated by peripheral catecholamines. To ascertain the role of sympathetic nerve terminals in the cardiovascular effects of these peptides, we used bretylium tosylate to prevent nerve terminal release of norepinephrine. Pretreatment with bretylium significantly attenuated the pressor and cardioaccelerator responses of gamma 2-MSH, and shifted the peak of the remaining responses to a later time point. It appears that the acute cardiovascular response to gamma-MSH administration depends primarily on the release of sympathetic terminal norepinephrine, though some contribution from other pressor systems such as adrenal catecholamines is possible.
促肾上腺皮质激素4 - 10/γ2 - 促黑激素3 - 9类肽静脉给药后会产生升压和心脏加速效应。这些作用似乎是由外周儿茶酚胺介导的。为了确定交感神经末梢在这些肽的心血管效应中的作用，我们使用溴苄铵来阻止神经末梢释放去甲肾上腺素。用溴苄铵预处理可显著减弱γ2 - 促黑激素的升压和心脏加速反应，并将剩余反应的峰值推迟到稍后的时间点。似乎γ - 促黑激素给药后的急性心血管反应主要取决于交感神经末梢去甲肾上腺素的释放，不过其他升压系统如肾上腺儿茶酚胺也可能有一定作用。
