Gruber K A, Klein M C, Hutchins P M, Buckalew V M, Lymangrover J R
Hypertension. 1984 Jul-Aug;6(4):468-74. doi: 10.1161/01.hyp.6.4.468.
The hypertensive and natriuretic effects of chronic administration of adrenocorticotrophic hormone (ACTH) cannot be duplicated by the administration of glucocorticoids and/or mineralocorticoids. We investigated the effects of a fragment of this hormone (ACTH4-10) and an analog of the fragment (D-Phe7) ACTH4-10 and found them to have pressor and cardioaccelerator actions in rats as determined by bolus intravenous (i.v.) injections of 30 to 1000 nmol/kg. The pressor and cardioaccelerator effects of (D-Phe7) ACTH4-10 were attenuated by alpha-receptor (phentolamine) and beta-receptor (metoprolol) antagonists. The cardiovascular actions of ACTH4-10 were produced in adrenalectomized or ganglionic-blocked (with mecamylamine) rats. At a lower dose (7 nmol/kg i.v.), ACTH4-10 was natriuretic and had a pattern of activity similar to that of a larger ACTH fragment, alpha-melanocyte-stimulating hormone. Extraadrenal effects of the intact ACTH molecule or the in vivo production of an ACTH4-10-like fragment from ACTH may contribute to the hypertensive and natriuretic actions associated with this hormone.
长期给予促肾上腺皮质激素（ACTH）所产生的高血压和利钠作用，无法通过给予糖皮质激素和/或盐皮质激素来复制。我们研究了该激素的一个片段（ACTH4 - 10）及其类似物（D - Phe7）ACTH4 - 10的作用，发现通过静脉推注30至1000 nmol/kg，它们在大鼠中具有升压和心脏加速作用。（D - Phe7）ACTH4 - 10的升压和心脏加速作用可被α受体拮抗剂（酚妥拉明）和β受体拮抗剂（美托洛尔）减弱。ACTH4 - 10的心血管作用在肾上腺切除或神经节阻断（用美加明）的大鼠中也会产生。在较低剂量（静脉注射7 nmol/kg）时，ACTH4 - 10具有利钠作用，其活性模式与较大的ACTH片段α - 黑素细胞刺激素相似。完整ACTH分子的肾上腺外作用或体内从ACTH产生类似ACTH4 - 10的片段，可能有助于该激素相关的高血压和利钠作用。
