• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

作为靶向DNA拓扑异构酶的抗癌剂的天然化合物

Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases.

作者信息

Jain Chetan Kumar, Majumder Hemanta Kumar, Roychoudhury Susanta

机构信息

Infectious Diseases and Immunology Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S.C. Mullick Road, Jadavpur, Kolkata-700032, India.

Division of Research, Saroj Gupta Cancer Centre & Research Institute, M G Road, Thakurpukur, Kolkata-700 063, India.

出版信息

Curr Genomics. 2017 Feb;18(1):75-92. doi: 10.2174/1389202917666160808125213.

DOI:10.2174/1389202917666160808125213
PMID:28503091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5321768/
Abstract

DNA topoisomerases are important cellular enzymes found in almost all types of living cells (eukaryotic and prokaryotic). These enzymes are essential for various DNA metabolic processes e.g. replication, transcription, recombination, chromosomal decatenation etc. These enzymes are important molecular drug targets and inhibitors of these enzymes are widely used as effective anticancer and antibacterial drugs. However, topoisomerase inhibitors have some therapeutic limitations and they exert serious side effects during cancer chemotherapy. Thus, development of novel anticancer topoisomerase inhibitors is necessary for improving cancer chemotherapy. Nature serves as a repertoire of structurally and chemically diverse molecules and in the recent years many DNA topoisomerase inhibitors have been identified from natural sources. The present review discusses anticancer properties and therapeutic importance of eighteen recently identified natural topoisomerase inhibitors (from the year 2009 to 2015). Structural characteristics of these novel inhibitors provide backbones for designing and developing new anticancer drugs.

摘要

DNA拓扑异构酶是几乎在所有类型的活细胞（真核细胞和原核细胞）中都能找到的重要细胞酶。这些酶对于各种DNA代谢过程至关重要，例如复制、转录、重组、染色体解连环等。这些酶是重要的分子药物靶点，其抑制剂被广泛用作有效的抗癌和抗菌药物。然而，拓扑异构酶抑制剂存在一些治疗局限性，并且在癌症化疗期间会产生严重的副作用。因此，开发新型抗癌拓扑异构酶抑制剂对于改善癌症化疗是必要的。自然界是结构和化学性质多样的分子库，近年来已从天然来源鉴定出许多DNA拓扑异构酶抑制剂。本综述讨论了最近鉴定出的18种天然拓扑异构酶抑制剂（2009年至2015年）的抗癌特性和治疗重要性。这些新型抑制剂的结构特征为设计和开发新的抗癌药物提供了基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/24c5ac59db0d/CG-18-75_F8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/1d548de779d8/CG-18-75_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/10ac587438b4/CG-18-75_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/8b7ef0636499/CG-18-75_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/455dae67d794/CG-18-75_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/2ee2cc3f32f2/CG-18-75_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/002d2d80c404/CG-18-75_F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/fdb89b81b192/CG-18-75_F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/24c5ac59db0d/CG-18-75_F8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/1d548de779d8/CG-18-75_F1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/10ac587438b4/CG-18-75_F2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/8b7ef0636499/CG-18-75_F3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/455dae67d794/CG-18-75_F4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/2ee2cc3f32f2/CG-18-75_F5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/002d2d80c404/CG-18-75_F6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/fdb89b81b192/CG-18-75_F7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f614/5321768/24c5ac59db0d/CG-18-75_F8.jpg

相似文献

1
Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases.作为靶向DNA拓扑异构酶的抗癌剂的天然化合物
Curr Genomics. 2017 Feb;18(1):75-92. doi: 10.2174/1389202917666160808125213.
2
Secondary metabolites as DNA topoisomerase inhibitors: A new era towards designing of anticancer drugs.作为DNA拓扑异构酶抑制剂的次生代谢产物：抗癌药物设计的新时代。
Pharmacogn Rev. 2010 Jan;4(7):12-26. doi: 10.4103/0973-7847.65320.
3
Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseases.探索DNA拓扑异构酶作为新型治疗药物治疗传染病的靶点。
Infect Disord Drug Targets. 2007 Mar;7(1):3-9. doi: 10.2174/187152607780090748.
4
Multiple Topoisomerase I (TopoI), Topoisomerase II (TopoII) and Tyrosyl-DNA Phosphodiesterase (TDP) inhibitors in the development of anticancer drugs.多种拓扑异构酶 I（TopoI）、拓扑异构酶 II（TopoII）和酪氨酰-DNA 磷酸二酯酶（TDP）抑制剂在抗癌药物的开发中的应用。
Eur J Pharm Sci. 2021 Jan 1;156:105594. doi: 10.1016/j.ejps.2020.105594. Epub 2020 Oct 12.
5
Natural Products as Anti-Cancerous Therapeutic Molecules Targeted towards Topoisomerases.天然产物作为针对拓扑异构酶的抗癌治疗分子。
Curr Protein Pept Sci. 2020;21(11):1103-1142. doi: 10.2174/1389203721666200918152511.
6
Recent advances in the development of dual topoisomerase I and II inhibitors as anticancer drugs.近年来，双重拓扑异构酶 I 和 II 抑制剂作为抗癌药物的发展取得了进展。
Curr Med Chem. 2010;17(35):4270-90. doi: 10.2174/092986710793361252.
7
Topoisomerases: Resistance versus Sensitivity, How Far We Can Go?拓扑异构酶：耐药与敏感，我们能走多远？
Med Res Rev. 2017 Mar;37(2):404-438. doi: 10.1002/med.21417. Epub 2016 Sep 30.
8
Drugging topoisomerases: lessons and challenges.靶向拓扑异构酶药物：经验与挑战。
ACS Chem Biol. 2013 Jan 18;8(1):82-95. doi: 10.1021/cb300648v. Epub 2013 Jan 4.
9
Topoisomerase II inhibitors design: Early studies and new perspectives.拓扑异构酶 II 抑制剂设计：早期研究与新视角。
Bioorg Chem. 2023 Jul;136:106548. doi: 10.1016/j.bioorg.2023.106548. Epub 2023 Apr 20.
10
Topoisomerase Inhibitors and Targeted Delivery in Cancer Therapy.拓扑异构酶抑制剂与癌症治疗中的靶向递送。
Curr Top Med Chem. 2019;19(9):713-729. doi: 10.2174/1568026619666190401112948.

引用本文的文献

1
Inhibition of DNA Topoisomerase Ι by Flavonoids and Polyacetylenes Isolated from L.从 L. 中分离得到的黄酮类化合物和多炔类化合物对 DNA 拓扑异构酶 Ι 的抑制作用
Molecules. 2024 Jul 27;29(15):3547. doi: 10.3390/molecules29153547.
2
Anticancer Drug Discovery Based on Natural Products: From Computational Approaches to Clinical Studies.基于天然产物的抗癌药物发现：从计算方法到临床研究
Biomedicines. 2024 Jan 16;12(1):201. doi: 10.3390/biomedicines12010201.
3
Unveiling the therapeutic potential: Evaluation of anti-inflammatory and antineoplastic activity of Linn's stem bark isolate through molecular docking insights.

本文引用的文献

1
Plumbagin suppresses epithelial to mesenchymal transition and stemness via inhibiting Nrf2-mediated signaling pathway in human tongue squamous cell carcinoma cells.白花丹醌通过抑制人舌鳞状细胞癌细胞中Nrf2介导的信号通路来抑制上皮-间质转化和干性。
Drug Des Devel Ther. 2015 Oct 5;9:5511-51. doi: 10.2147/DDDT.S89621. eCollection 2015.
2
Inhibition of Topoisomerase (DNA) I (TOP1): DNA Damage Repair and Anticancer Therapy.拓扑异构酶（DNA）I（TOP1）的抑制：DNA损伤修复与抗癌治疗
Biomolecules. 2015 Jul 22;5(3):1652-70. doi: 10.3390/biom5031652.
3
Vosaroxin plus cytarabine versus placebo plus cytarabine in patients with first relapsed or refractory acute myeloid leukaemia (VALOR): a randomised, controlled, double-blind, multinational, phase 3 study.
揭示治疗潜力：通过分子对接见解评估 Linn 茎皮提取物的抗炎和抗肿瘤活性。
Heliyon. 2023 Dec 3;10(1):e22972. doi: 10.1016/j.heliyon.2023.e22972. eCollection 2024 Jan 15.
4
Evaluation of topotecan and 10-hydroxycamptothecin on Toxoplasma gondii: Implications on baseline DNA damage and repair efficiency.评价拓扑替康和 10-羟基喜树碱对弓形虫的作用：对基础 DNA 损伤和修复效率的影响。
Int J Parasitol Drugs Drug Resist. 2023 Dec;23:120-129. doi: 10.1016/j.ijpddr.2023.11.004. Epub 2023 Nov 24.
5
Nanotoxicity of multifunctional stoichiometric cobalt oxide nanoparticles (SCoONPs) with repercussions toward apoptosis, necrosis, and cancer necrosis factor (TNF-α) at nano-biointerfaces.多功能化学计量比氧化钴纳米颗粒（SCoONPs）在纳米生物界面的纳米毒性及其对细胞凋亡、坏死和肿瘤坏死因子（TNF-α）的影响。
Toxicol Res (Camb). 2023 Sep 29;12(5):716-740. doi: 10.1093/toxres/tfad086. eCollection 2023 Oct.
6
Does the Mineral Composition of Volcanic Ashes Have a Beneficial or Detrimental Impact on the Soils and Cultivated Crops of Ecuador?火山灰的矿物质成分对厄瓜多尔的土壤和种植作物有有益影响还是有害影响？
Toxics. 2023 Oct 10;11(10):846. doi: 10.3390/toxics11100846.
7
Effects of In Vitro Digestion of Polyphenols from Coffee on Binding Parameters to Human Topoisomerase II α.咖啡多酚的体外消化对人拓扑异构酶 IIα 结合参数的影响。
Molecules. 2023 Aug 10;28(16):5996. doi: 10.3390/molecules28165996.
8
Chemical Constituents, Anticancer and Anti-Proliferative Potential of Species: A Systematic Review.物种的化学成分、抗癌及抗增殖潜力：一项系统综述
Pharmaceuticals (Basel). 2023 Feb 14;16(2):293. doi: 10.3390/ph16020293.
9
Recent Developments in Combination Chemotherapy for Colorectal and Breast Cancers with Topoisomerase Inhibitors.拓扑异构酶抑制剂在结直肠癌和乳腺癌联合化疗中的最新进展。
Int J Mol Sci. 2023 May 8;24(9):8457. doi: 10.3390/ijms24098457.
10
Targeting DNA Topoisomerase II in Antifungal Chemotherapy.抗真菌化疗中靶向 DNA 拓扑异构酶 II
Molecules. 2022 Nov 11;27(22):7768. doi: 10.3390/molecules27227768.
伏沙罗辛联合阿糖胞苷对比安慰剂联合阿糖胞苷治疗初治复发或难治性急性髓系白血病患者（VALOR）：一项随机、对照、双盲、多中心3期研究
Lancet Oncol. 2015 Sep;16(9):1025-1036. doi: 10.1016/S1470-2045(15)00201-6. Epub 2015 Jul 30.
4
Vosaroxin in acute myeloid leukaemia.
Lancet Oncol. 2015 Sep;16(9):1000-1001. doi: 10.1016/S1470-2045(15)00165-5. Epub 2015 Jul 30.
5
Sulfonoquinovosyl diacylglyceride selectively targets acute lymphoblastic leukemia cells and exerts potent anti-leukemic effects in vivo.磺基喹喔啉基二酰基甘油选择性靶向急性淋巴细胞白血病细胞，并在体内发挥强大的抗白血病作用。
Sci Rep. 2015 Jul 20;5:12082. doi: 10.1038/srep12082.
6
Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer.水甘草酸破坏EZH2-EED复合物的相互作用并抑制PRC2依赖性癌症。
Oncotarget. 2015 May 30;6(15):13049-59. doi: 10.18632/oncotarget.3790.
7
Daurinol Enhances the Efficacy of Radiotherapy in Lung Cancer via Suppression of Aurora Kinase A/B Expression.道立诺通过抑制 Aurora 激酶 A/B 的表达增强肺癌放疗疗效。
Mol Cancer Ther. 2015 Jul;14(7):1693-704. doi: 10.1158/1535-7163.MCT-14-0960. Epub 2015 Apr 16.
8
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition.人类癌症中的基因组不稳定性：分子见解以及通过饮食和营养进行治疗性攻击和预防的机会。
Semin Cancer Biol. 2015 Dec;35 Suppl(Suppl):S5-S24. doi: 10.1016/j.semcancer.2015.03.005. Epub 2015 Apr 11.
9
Plumbagin induces G2/M arrest, apoptosis, and autophagy via p38 MAPK- and PI3K/Akt/mTOR-mediated pathways in human tongue squamous cell carcinoma cells.白花丹醌通过p38丝裂原活化蛋白激酶和磷脂酰肌醇-3-激酶/蛋白激酶B/哺乳动物雷帕霉素靶蛋白介导的信号通路诱导人舌鳞状细胞癌细胞发生G2/M期阻滞、凋亡和自噬。
Drug Des Devel Ther. 2015 Mar 16;9:1601-26. doi: 10.2147/DDDT.S76057. eCollection 2015.
10
Selective killing of G2 decatenation checkpoint defective colon cancer cells by catalytic topoisomerase II inhibitor.通过催化性拓扑异构酶II抑制剂选择性杀伤G2解连环检查点缺陷的结肠癌细胞
Biochim Biophys Acta. 2015 May;1853(5):1195-204. doi: 10.1016/j.bbamcr.2015.02.021. Epub 2015 Mar 4.