Guibas George V, Mathioudakis Alexander G, Tsoumani Marina, Tsabouri Sophia
Division of Infection, Immunity and Respiratory Medicine, University Hospital of South Manchester, University of Manchester, Manchester, UK.
Child Health Department, School of Medicine, University of Ioannina, Ioannina, Greece.
Front Pediatr. 2017 Apr 28;5:92. doi: 10.3389/fped.2017.00092. eCollection 2017.
Asthma and allergy share a similar and very close course, especially through childhood. Considerable research effort has been put in untangling these associations; however, it is now becoming obvious that this is an exceedingly difficult task. In fact, each research breakthrough further perplexes this picture, as we are steadily moving toward the era of personalized medicine and we begin to appreciate that what we thought to be a single disease, asthma, is in fact an accumulation of distinct entities. In the context of this "syndrome," which is characterized by several, as of yet poorly defined endotypes and phenotypes, the question of the link of "asthma" with allergy probably becomes non-relevant. In this review, we will revisit this question while putting the emphasis on the multifaceted nature of asthma.
哮喘和过敏有着相似且紧密相关的病程，尤其是在儿童时期。为理清这些关联，人们付出了大量的研究努力；然而，现在很明显这是一项极其困难的任务。事实上，每一项研究突破都使情况更加复杂，因为我们正稳步迈向个性化医疗时代，并且开始认识到我们原本认为是单一疾病的哮喘，实际上是多种不同实体的集合。在这种以几种尚未明确界定的内型和表型为特征的“综合征”背景下，“哮喘”与过敏之间联系的问题可能就变得无关紧要了。在本综述中，我们将重新审视这个问题，同时强调哮喘的多面性。
