Gupta Amar, Dixon Elijah
Department of Surgery, University of Calgary, Foothills Medical Centre, Calgary, Alberta, Canada.
Hepatobiliary Surg Nutr. 2017 Apr;6(2):101-104. doi: 10.21037/hbsn.2017.01.02.
Intrahepatic cholangiocarcinoma (ICC) is a rare entity with a distinct clinical course and epidemiology from hilar and extrahepatic cholangiocarcinoma. ICC makes up 8-10% of cholangiocarcinomas and 10-20% of all primary liver tumors. There remains a considerable amount of geographic variation in the incidence of ICC worldwide; however, the overall incidence of this malignancy appears to be rising. Several risk factors have been identified, such as infectious causes (liver flukes, viral hepatitis), biliary tract disease [primary sclerosing cholangitis (PSC), hepaticolithiasis, biliary cystic diseases], metabolic syndrome, lifestyle choices (alcohol abuse, tobacco use), and cirrhosis. Despite this, a substantial number of ICC patients do not have any identifiable risk factors, underlining the need for further work into the pathogenesis of this malignancy.
肝内胆管癌（ICC）是一种罕见的疾病，其临床病程和流行病学特征与肝门部胆管癌及肝外胆管癌不同。ICC占胆管癌的8%-10%，占所有原发性肝癌的10%-20%。全球范围内，ICC的发病率存在相当大的地域差异；然而，这种恶性肿瘤的总体发病率似乎在上升。已确定了多种危险因素，如感染因素（肝吸虫、病毒性肝炎）、胆道疾病[原发性硬化性胆管炎（PSC）、肝内胆管结石、胆管囊性疾病]、代谢综合征、生活方式选择（酗酒、吸烟）以及肝硬化。尽管如此，相当一部分ICC患者没有任何可识别的危险因素，这突出了对该恶性肿瘤发病机制进行进一步研究的必要性。
