Tan Wei Wei, Chan Derrick W S, Lee Jan Hau, Thomas Terrence, Menon Anuradha P, Chan Yoke Hwee
Department of Pharmacy, KK Women's and Children's Hospital, Singapore, Singapore.
Department of Paediatrics, Pediatric Neurology, KK Women's and Children's Hospital, Singapore.
Child Neurol Open. 2015 Mar 23;2(1):2329048X14550067. doi: 10.1177/2329048X14550067. eCollection 2015 Jan-Mar.
Febrile illness-related epilepsy syndrome is a catastrophic epileptic encephalopathy that is highly refractory to most antiepileptic drugs leading to high morbidity and mortality. The authors report the use of a pediatric infusion protocol of continuous intravenous magnesium sulfate for the control of seizures in 2 children with febrile illness-related epilepsy syndrome refractory to multiple antiepileptic drugs in a pediatric intensive care unit of a tertiary care children's hospital. Both patients, 2 and 16 years of age, respectively, were treated with continuous magnesium sulfate infusion. Serum magnesium concentrations ranging from 2.1 to 5 mmol/L were achieved. Seizure reduction and cessation were noted in 1 patient with magnesium more than 3.0 mmol/L. No significant adverse effects were observed. Magnesium sulfate infusions can be safely used in pediatric refractory status epilepticus. Magnesium sulfate can be considered in the management of children with febrile illness-related epilepsy syndrome.
发热性疾病相关癫痫综合征是一种灾难性的癫痫性脑病，对大多数抗癫痫药物具有高度难治性，导致高发病率和死亡率。作者报告了在一家三级儿童专科医院的儿科重症监护病房中，使用小儿静脉持续输注硫酸镁方案来控制2例对多种抗癫痫药物难治的发热性疾病相关癫痫综合征患儿的癫痫发作。两名患者分别为2岁和16岁，均接受了硫酸镁持续输注治疗。血清镁浓度达到2.1至5 mmol/L。1例血清镁浓度超过3.0 mmol/L的患者癫痫发作减少并停止。未观察到明显不良反应。硫酸镁输注可安全用于小儿难治性癫痫持续状态。对于发热性疾病相关癫痫综合征患儿的治疗可考虑使用硫酸镁。
