Khan Adil Mehraj, Raina Rajinder, Dubey Nitin, Verma Pawan Kumar
a Division of Veterinary Pharmacology and Toxicology , Sher-e-Kashmir University of Agricultural Sciences and Technology of Jammu , Jammu , India.
Drug Chem Toxicol. 2018 Apr;41(2):123-127. doi: 10.1080/01480545.2017.1321009. Epub 2017 May 15.
The study evaluated the effect of commercial preparation of deltamethrin, Butox, and fluoride (F) co-exposure on the brain antioxidant status and cholinesterase activity in rats. Group A was untreated. Group B was gavaged Butox, providing deltamethrin at the dose rate of 1.28 mg per kg body weight per day. Group C was administered F, as NaF, in drinking water providing 20 ppm F. Group D received both deltamethrin and F at the same dosages as groups B and C, respectively. Although, glutathione S-transferase activity was induced only in Butox alone treated group, the activities of superoxide dismutase and catalase were inhibited in all treatment groups when compared to the control group. Elevated lipid peroxidation was observed in the groups exposed to F. The activity of erythrocyte acetylcholinesterase (AChE) was inhibited in Butox treated groups, whereas brain AChE activity was inhibited in all treatment groups. In conclusion, both deltamethrin (given as Butox) and F inhibit AChE activity and produce oxidative stress in brain with F producing more oxidative damage. However, compared to the individual exposures, the co-exposure of these chemicals does not produce any exacerbated alteration in these biochemical parameters.
该研究评估了溴氰菊酯商业制剂Butox与氟化物（F）共同暴露对大鼠脑抗氧化状态和胆碱酯酶活性的影响。A组未接受处理。B组经口灌胃给予Butox，按每天每千克体重1.28毫克的剂量率提供溴氰菊酯。C组在饮用水中给予F（以氟化钠形式），提供20 ppm的F。D组分别以与B组和C组相同的剂量同时接受溴氰菊酯和F。尽管仅在单独使用Butox处理的组中诱导了谷胱甘肽S-转移酶活性，但与对照组相比，所有处理组中超氧化物歧化酶和过氧化氢酶的活性均受到抑制。在暴露于F的组中观察到脂质过氧化升高。在Butox处理的组中红细胞乙酰胆碱酯酶（AChE）活性受到抑制，而在所有处理组中脑AChE活性均受到抑制。总之，溴氰菊酯（以Butox形式给予）和F均抑制AChE活性并在脑中产生氧化应激，其中F产生更多的氧化损伤。然而，与单独暴露相比，这些化学物质的共同暴露在这些生化参数上并未产生任何加剧的改变。
