Haen E, Langenmayer I, Pangerl A, Liebl B, Remien J
Walther-Straub-Insitut für Pharmakologie und Toxikologie, München.
Klin Wochenschr. 1988 Jul 1;66(13):579-82. doi: 10.1007/BF01720832.
Peripheral mononuclear leukocytes (MNLs) are widely used as a tissue model in studies of beta-adrenoceptor disturbances in hypertension and asthmatic diseases. The beta 2-adrenoceptor density (Bmax), however, depends not only on the gender of the person under study and on the time of day the blood specimens are obtained. Evidence is now reported for a circannual variation in the expression of beta 2-adrenoceptor sites on peripheral MNLs. In male volunteers the 24-h mean was found to be highest in the men studied in April/May (1135 +/- 10 sites/cell) and decreased to 891 +/- 16 sites/cell in August and to 712 +r90 sites/cell in December (means +/- SE, P less than 0.01 April/May compared to December). Concomitantly the circadian amplitude increased from 17.3% +/- 6.4% of 24-h mean in April/May to 28.2% +/- 1.4% of 24-h mean in August and to 34.2% +/- 4.2% of 24-h mean in December (means +/- SE, P less than 0.05, April/May compared to December). The circadian acrophase remained constant (190 degrees +/- 30 degrees equivalent to 12 h 40 min +/- 2 h 00 min, means +/- SE).
外周血单个核白细胞（MNLs）在高血压和哮喘疾病中β-肾上腺素能受体紊乱的研究中被广泛用作组织模型。然而，β2-肾上腺素能受体密度（Bmax）不仅取决于研究对象的性别以及采集血样的时间。现在有证据表明外周血MNLs上β2-肾上腺素能受体位点的表达存在年周期变化。在男性志愿者中，发现4月/5月研究的男性24小时平均值最高（1135±10个位点/细胞），8月降至891±16个位点/细胞，12月降至712±90个位点/细胞（平均值±标准误，4月/5月与12月相比P<0.01）。同时，昼夜振幅从4月/5月占24小时平均值的17.3%±6.4%增加到8月占24小时平均值的28.2%±1.4%，12月占24小时平均值的34.2%±4.2%（平均值±标准误，4月/5月与12月相比P<0.05）。昼夜峰相位保持不变（190°±30°相当于12小时40分钟±2小时00分钟，平均值±标准误）。
