Allgayer H, Kruis W, Erdmann E
Medizinische Klinik II, Klinikum Grosshadern, Universität München.
Klin Wochenschr. 1988 Jul 1;66(13):599-600. doi: 10.1007/BF01720836.
The effects of lipoxygenase products (5-, 12-, 15-HETE, LTB4) and superoxide radicals on human colonic (Na+ + K+)-ATPase and specific ouabain binding were measured. No significant inhibition in concentrations up to 3 x 10(-5) M was observed. The results are discussed with regard to a possible role of lipoxygenase products and radicals in the pathogenesis of water and electrolyte disturbances in various diarrheal states including inflammatory bowel disease.
测定了脂氧合酶产物（5-、12-、15-羟基二十碳四烯酸、白三烯B4）和超氧自由基对人结肠（Na+ + K+）-ATP酶及特异性哇巴因结合的影响。在浓度高达3×10(-5) M时未观察到显著抑制作用。结合脂氧合酶产物和自由基在包括炎症性肠病在内的各种腹泻状态下水和电解质紊乱发病机制中的可能作用对结果进行了讨论。
