Heldmann Marcus, Münte Thomas F, Paracka Lejla, Beyer Frederike, Brüggemann Norbert, Saryyeva Assel, Rasche Dirk, Krauss Joachim K, Tronnier Volker M
Department of Neurology, University of Lübeck, Lübeck, Germany; Institute of Psychology II, University of Lübeck, Lübeck, Germany.
Department of Neurology, University of Lübeck, Lübeck, Germany; Institute of Psychology II, University of Lübeck, Lübeck, Germany.
Neuroscience. 2017 Jul 4;355:141-148. doi: 10.1016/j.neuroscience.2017.05.008. Epub 2017 May 11.
The subthalamic nucleus (STN) shapes motor behavior and is important for the initiation and termination of movements. Here we ask whether the STN takes aggregated sensory information into account, in order to exert this function. To this end, local field potentials (LFP) were recorded in eight patients suffering from Parkinson's disease and receiving deep-brain stimulation of the STN bilaterally. Bipolar recordings were obtained postoperatively from the externalized electrode leads. Patients were passively exposed to trains of auditory stimuli containing global deviants, local deviants or combined global/local deviants. The surface event-related potentials of the Parkinson's patients as well as those of 19 age-matched healthy controls were characterized by a mismatch negativity (MMN) that was most pronounced for the global/local double deviants and less prominent for the other deviant conditions. The left and right STN LFPs similarly were modulated by stimulus deviance starting at about 100ms post-stimulus onset. The MMN has been viewed as an index of an automatic auditory change detection system, more recently phrased in terms of predictive coding theory, which prepares the organism for attention shifts and for action. The LFP-data from the STN clearly demonstrate that the STN receives information on stimulus deviance, possibly as a means to bias the system to interrupt ongoing and to allow alternative actions.
丘脑底核（STN）塑造运动行为，对运动的起始和终止很重要。在此，我们探究STN是否会考虑整合的感觉信息以发挥这一功能。为此，我们记录了8名帕金森病患者双侧丘脑底核深部脑刺激时的局部场电位（LFP）。术后从外置电极导联获得双极记录。让患者被动暴露于包含全局偏差、局部偏差或全局/局部组合偏差的一系列听觉刺激中。帕金森病患者以及19名年龄匹配的健康对照者的表面事件相关电位以失匹配负波（MMN）为特征，该负波在全局/局部双重偏差时最为明显，在其他偏差条件下则不那么突出。左右丘脑底核局部场电位同样在刺激开始后约100毫秒受到刺激偏差的调制。MMN被视为自动听觉变化检测系统的指标，最近根据预测编码理论进行阐述，该理论使机体为注意力转移和行动做好准备。来自丘脑底核的局部场电位数据清楚地表明，丘脑底核接收有关刺激偏差的信息，这可能是一种使系统偏向于中断正在进行的活动并允许采取替代行动的手段。
