血清素系统与贪食症的关联。

Involvement of serotonin system in bulimia.

作者信息

Marazziti D, Macchi E, Rotondo A, Placidi G F, Cassano G B

机构信息

Department of Psychiatry, Medical School, University of Pisa, Italy.

出版信息

Life Sci. 1988;43(25):2123-6. doi: 10.1016/0024-3205(88)90362-1.

DOI:10.1016/0024-3205(88)90362-1

PMID:2850422

Abstract

Platelet 3H-imipramine binding was investigated in 8 patients affected by bulimia according to DSM III criteria, and in 7 healthy volunteers. The Bmax +/- SD (fmol/mg protein) was 356 +/- 53 in patients, and 1144 +/- 134 in controls. The Kd +/- SD (nM) was 1.35 +/- 0.44 in patients, and 1.90 +/- 0.72 in controls. There was a significant difference (p less than 0.0001) in Bmax values in the two groups, whereas no significant difference was observed in Kd values. This study suggests the possible involvement of the indoleamine system in bulimia.

摘要

根据《精神疾病诊断与统计手册》第三版标准，对8名贪食症患者和7名健康志愿者的血小板3H-丙咪嗪结合情况进行了研究。患者的最大结合容量（Bmax）±标准差（fmol/mg蛋白）为356±53，对照组为1144±134。患者的解离常数（Kd）±标准差（nM）为1.35±0.44，对照组为1.90±0.72。两组的Bmax值存在显著差异（p<0.0001），而Kd值无显著差异。该研究表明吲哚胺系统可能参与了贪食症的发病过程。