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1
Decreased platelet 3H-imipramine binding sites in classical migraine.典型偏头痛患者血小板3H-丙咪嗪结合位点减少。
J Neurol Neurosurg Psychiatry. 1984 Jul;47(7):720-3. doi: 10.1136/jnnp.47.7.720.
2
Dieting and weight loss in volunteers increases the number of alpha 2-adrenoceptors and 5-HT receptors on blood platelets without effect on [3H]imipramine binding.
J Affect Disord. 1987 May-Jun;12(3):267-74. doi: 10.1016/0165-0327(87)90037-1.
3
Platelet [3H]imipramine binding in migraine and tension headache in relation to depression.
J Psychiatr Res. 1991;25(4):205-11. doi: 10.1016/0022-3956(91)90025-6.
4
Reduced Vmax of 3H-serotonin uptake but unchanged 3H-imipramine binding in the platelets of untreated hypertensive subjects.未经治疗的高血压患者血小板中3H-血清素摄取的最大速率降低，但3H-丙咪嗪结合不变。
Life Sci. 1984 May 21;34(21):2083-8. doi: 10.1016/0024-3205(84)90373-4.
5
Differential 3H-imipramine platelet binding in patients with panic disorder and depression.惊恐障碍和抑郁症患者中3H-丙咪嗪血小板结合的差异
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Decreased platelet 3H-imipramine binding in Parkinson's disease.
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High affinity 3H-imipramine binding in human platelets: age and sex effects.
Neuropsychobiology. 1984;11(3):178-80. doi: 10.1159/000118073.
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Seasonal variation of platelet serotonin uptake and 3H-imipramine binding in normal and depressed subjects.正常人和抑郁症患者血小板5-羟色胺摄取及3H-丙咪嗪结合的季节性变化
Biol Psychiatry. 1986 Mar;21(3):283-92. doi: 10.1016/0006-3223(86)90049-1.
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Lack of association between [3H]imipramine binding sites and uptake of serotonin in control, depressed and schizophrenic patients.[3H]丙咪嗪结合位点与对照、抑郁和精神分裂症患者中血清素摄取之间缺乏关联。
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Platelet serotonin uptake and migraine.血小板5-羟色胺摄取与偏头痛
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Tritiated imipramine binding sites are decreased in the frontal cortex of suicides.自杀者额叶皮质中氚标记的丙咪嗪结合位点减少。
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Changes in regional cerebral blood flow during the course of classic migraine attacks.典型偏头痛发作过程中局部脑血流量的变化。
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典型偏头痛患者血小板3H-丙咪嗪结合位点减少。

Decreased platelet 3H-imipramine binding sites in classical migraine.

作者信息

Geaney D P, Rutterford M G, Elliott J M, Schächter M, Peet K M, Grahame-Smith D G

出版信息

J Neurol Neurosurg Psychiatry. 1984 Jul;47(7):720-3. doi: 10.1136/jnnp.47.7.720.

DOI:10.1136/jnnp.47.7.720
PMID:6086845
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1027901/
Abstract

Patients with classical migraine investigated between attacks had significantly fewer platelet 3H-imipramine binding sites than control subjects and this finding was more marked in males than in females. There was no abnormality of binding characteristics of platelet 5-hydroxytryptamine receptors or of platelet alpha 2-adrenoceptors. Because the reduced 3H-imipramine binding capacity was found in classical migraineurs who were investigated between attacks, it may reflect a predisposition to migraine rather than being a consequence of attacks.

摘要

在发作间期接受调查的典型偏头痛患者，其血小板3H-丙咪嗪结合位点显著少于对照组，且这一发现男性比女性更为明显。血小板5-羟色胺受体或血小板α2-肾上腺素能受体的结合特性没有异常。由于在发作间期接受调查的典型偏头痛患者中发现3H-丙咪嗪结合能力降低，这可能反映了偏头痛的易感性，而非发作的结果。