典型偏头痛患者血小板3H-丙咪嗪结合位点减少。
Decreased platelet 3H-imipramine binding sites in classical migraine.
作者信息
Geaney D P, Rutterford M G, Elliott J M, Schächter M, Peet K M, Grahame-Smith D G
出版信息
J Neurol Neurosurg Psychiatry. 1984 Jul;47(7):720-3. doi: 10.1136/jnnp.47.7.720.
Abstract
Patients with classical migraine investigated between attacks had significantly fewer platelet 3H-imipramine binding sites than control subjects and this finding was more marked in males than in females. There was no abnormality of binding characteristics of platelet 5-hydroxytryptamine receptors or of platelet alpha 2-adrenoceptors. Because the reduced 3H-imipramine binding capacity was found in classical migraineurs who were investigated between attacks, it may reflect a predisposition to migraine rather than being a consequence of attacks.
摘要
在发作间期接受调查的典型偏头痛患者，其血小板3H-丙咪嗪结合位点显著少于对照组，且这一发现男性比女性更为明显。血小板5-羟色胺受体或血小板α2-肾上腺素能受体的结合特性没有异常。由于在发作间期接受调查的典型偏头痛患者中发现3H-丙咪嗪结合能力降低，这可能反映了偏头痛的易感性，而非发作的结果。
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