大隅良典因自噬机制获得诺贝尔奖：从酵母基础生物学到治疗潜力

Yoshinori Ohsumi's Nobel Prize for mechanisms of autophagy: from basic yeast biology to therapeutic potential.

作者信息

Rubinsztein D C, Frake R A

机构信息

DC Rubinsztein, Department of Medical Genetics, Cambridge Institute for Medical Research, Cambridge Biomedical Campus, Hills Road, Cambridge CB2 0XY, UK. E-mail

出版信息

J R Coll Physicians Edinb. 2016 Dec;46(4):228-233. doi: 10.4997/jrcpe.2016.403.

DOI:10.4997/jrcpe.2016.403

PMID:28504774

Abstract

On 3 October 2016, Japanese cell biologist Yoshinori Ohsumi was awarded the Nobel Prize in Physiology or Medicine 'for his discoveries of mechanisms for autophagy'; autophagy being an intracellular degradation pathway that helps maintain cytoplasmic homeostasis. This commentary discusses Ohsumi's Nobel prize-winning work in context, before explaining the clinical relevance of autophagy.

摘要

2016年10月3日，日本细胞生物学家大隅良典因“发现自噬的机制”而被授予诺贝尔生理学或医学奖；自噬是一种有助于维持细胞质稳态的细胞内降解途径。本评论先在相关背景下讨论了大隅良典的诺贝尔奖获奖成果，然后解释了自噬的临床意义。