Gogna G, Patel N, Bilinski P
G Gogna, Greenslopes Private Hospital, Newdegate Street, Greenslopes 4120, Brisbane, QLD, Australia. E-mail
J R Coll Physicians Edinb. 2016 Dec;46(4):238-240. doi: 10.4997/JRCPE.2016.405.
Renal cell carcinoma has previously been associated with hypoglycaemia in the setting of non-islet cell tumours, caused by a paraneoplastic phenomenon relating to the production of insulin-like growth factor type II. We present a case of recurrent clear cell renal cell carcinoma, leading to an insulin-mediated paraneoplastic phenomenon causing severe recurrent hypoglycaemia. Hypoglycaemina was managed successfully using diazoxide therapy, in conjunction with pazopanib and radiotherapy to reduce tumour burden.
肾细胞癌此前已在非胰岛细胞瘤的情况下与低血糖相关联，这是由与胰岛素样生长因子II型产生相关的副肿瘤现象引起的。我们报告一例复发性透明细胞肾细胞癌病例，该病例导致胰岛素介导的副肿瘤现象，引起严重的复发性低血糖。使用二氮嗪治疗，并联合帕唑帕尼和放疗以减轻肿瘤负荷，成功地控制了低血糖。
