基于紧凑 LSPR 的光纤传感器的无标记 DNA 杂交检测。
Label-free detection of DNA hybridization with a compact LSPR-based fiber-optic sensor.
机构信息
Center for Applied Optics, University of Alabama at Huntsville, Huntsville, AL 35899, USA.
Department of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC 27401, USA.
出版信息
Analyst. 2017 Jun 7;142(11):1974-1981. doi: 10.1039/c7an00249a. Epub 2017 May 15.
Abstract
A miniaturized, robust, localized surface plasmon resonance (LSPR)-coupled fiber-optic (FO) nanoprobe providing an integrated and portable solution for detection of DNA hybridization and measurement of DNA concentrations has been demonstrated. The FO nanoprobe was created by constructing arrays of metallic nanostructures on the end facets of optical fibers utilizing nanofabrication technologies, including electron beam lithography and lift-off processes. The LSPR-FO nanoprobe device offers real-time, label-free, and low-sample-volume quantification of single-strand DNA in water with high sensitivity and selectivity, achieving a limit of detection around 10 fM. These results demonstrate the feasibility of the LSPR-FO nanoprobe device as a compact and low-cost biosensor for detection of short-strand DNA.
摘要
已经展示了一种微型化、稳健、局域表面等离子体共振 (LSPR) 耦合光纤 (FO) 纳米探针，为 DNA 杂交检测和 DNA 浓度测量提供了集成和便携式解决方案。FO 纳米探针是通过利用纳米制造技术（包括电子束光刻和剥离工艺）在光纤的端面构建金属纳米结构阵列而创建的。LSPR-FO 纳米探针器件具有实时、无标记和低样品体积定量检测水中单链 DNA 的能力，具有高灵敏度和选择性，检测限约为 10 fM。这些结果表明，LSPR-FO 纳米探针器件作为一种紧凑且低成本的生物传感器，可用于检测短链 DNA，具有可行性。
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