胆汁分泌机制：来自分离的大鼠肝细胞偶联的见解。
Mechanisms of bile secretion: insights from the isolated rat hepatocyte couplet.
作者信息
Boyer J L, Gautam A, Graf J
机构信息
Department of Medicine, Yale University School of Medicine, New Haven, CT 06510.
出版信息
Semin Liver Dis. 1988 Nov;8(4):308-16. doi: 10.1055/s-2008-1040552.
PMID:2850606
Abstract
This article reviews recent studies that have characterized the isolated rat hepatocyte couplet as a primary unit of canalicular bile formation. This cell culture system is proving to be particularly useful for identifying primary canalicular choleretics and for elucidating mechanisms of canalicular bile formation by electrophysiologic, fluorescent, and quantitative microscopic techniques.
摘要
本文综述了近期的研究，这些研究将分离的大鼠肝细胞双联体表征为胆小管胆汁形成的主要单位。事实证明，这种细胞培养系统对于鉴定原发性胆小管利胆药以及通过电生理、荧光和定量显微镜技术阐明胆小管胆汁形成机制特别有用。
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