García-García-de-Paredes Ana, Rodríguez-de-Santiago Enrique, Aguilera-Castro Lara, Ferre-Aracil Carlos, López-Sanromán Antonio
Sección de Gastroenterología, Servicio de Gastroenterología y Hepatología, Hospital Universitario Ramón y Cajal, Madrid, España.
Sección de Gastroenterología, Servicio de Gastroenterología y Hepatología, Hospital Universitario Ramón y Cajal, Madrid, España.
Gastroenterol Hepatol. 2015 Mar;38(3):123-34. doi: 10.1016/j.gastrohep.2014.07.010. Epub 2014 Nov 18.
Bacteria can no longer be seen as an enemy. Nowadays, there is enough evidence to place the microbiota as a key element in human homeostasis. Despite initial skepticism, fecal microbiota transplantation (FMT) is a real therapeutic alternative for patients with recurrent Clostridium difficile infection. Moreover, this procedure has shown promising results in ulcerative colitis and other non-gastrointestinal disorders. There is still a lack of knowledge and clinical trials with long- term follow-up. Therefore, the available data should be interpreted with caution. In this document we provide a detailed review of the literature on the intestinal microbiota and FMT.
细菌不再被视为敌人。如今,有足够的证据表明微生物群是人类体内平衡的关键要素。尽管最初存在怀疑,但粪便微生物群移植(FMT)对于复发性艰难梭菌感染患者而言是一种切实可行的治疗选择。此外,该程序在溃疡性结肠炎和其他非胃肠道疾病中也显示出了有前景的结果。目前仍缺乏长期随访的知识和临床试验。因此,对现有数据的解读应谨慎。在本文件中,我们对关于肠道微生物群和FMT的文献进行了详细综述。