Baskin G B, Murphey-Corb M, Watson E A, Martin L N
Delta Regional Primate Research Center, Tulane University, Covington, LA.
Vet Pathol. 1988 Nov;25(6):456-67. doi: 10.1177/030098588802500609.
Lesions induced in rhesus monkeys by different isolates of simian immunodeficiency virus (SIV)/Delta were studied at necropsy. Four groups of monkeys were inoculated with SIV/Delta isolated from other experimentally infected rhesus monkeys, while one group was inoculated with SIV/Delta from an asymptomatic mangabey monkey. Three rhesus isolates and the mangabey isolate were virulent, killing 75-100% of infected monkeys. One rhesus isolate, which had been extensively passaged in vitro, was attenuated but was restored to virulence by single animal passage. Clinically, infected monkeys had lymphadenopathy, splenomegaly, diarrhea, and a rash. Most monkeys died of enteric disease. The following lesions were seen: weight loss, thymic atrophy, lymphoid atrophy, bone marrow hyperplasia, encephalitis, colitis, amyloidosis, hepatitis, glomerulosclerosis, and the presence of syncytial cells. One Rh Epstein-Barr virus (EBV)-related lymphoma occurred. Opportunistic agents were identified: cytomegalovirus, adenovirus, Cryptosporidia, and Pneumocystis. Shigella and Campylobacter often caused colitis.
在尸检时研究了由不同猿猴免疫缺陷病毒（SIV）/Delta分离株诱导的恒河猴病变。四组猴子接种了从其他实验感染的恒河猴中分离出的SIV/Delta，而一组接种了来自无症状白眉猴的SIV/Delta。三种恒河猴分离株和白眉猴分离株具有毒性，导致75%-100%的感染猴子死亡。一种在体外广泛传代的恒河猴分离株减毒，但通过单动物传代恢复了毒性。临床上，感染的猴子有淋巴结病、脾肿大、腹泻和皮疹。大多数猴子死于肠道疾病。观察到以下病变：体重减轻、胸腺萎缩、淋巴组织萎缩、骨髓增生、脑炎、结肠炎、淀粉样变性、肝炎、肾小球硬化以及合胞体细胞的存在。发生了一例与恒河猴EB病毒（EBV）相关的淋巴瘤。鉴定出机会性病原体：巨细胞病毒、腺病毒、隐孢子虫和肺孢子菌。志贺菌和弯曲杆菌常引起结肠炎。
