King N W, Chalifoux L V, Ringler D J, Wyand M S, Sehgal P K, Daniel M D, Letvin N L, Desrosiers R C, Blake B J, Hunt R D
New England Regional Primate Research Center, Harvard Medical School, Southborough, MA.
J Med Primatol. 1990;19(2):109-18.
Epidemiologic and clinicopathologic data from 11 macaques with naturally acquired SIV infection--10 of which have died--were compared with those from 34 rhesus monkeys that have died of experimental SIVmac infection. Several differences, including gender affected, age at time of death, and the occurrence of certain opportunistic infections, could be explained by the experimental design; others remained unexplained. The most striking difference was the 41% incidence of meningoencephalomyelitis in the experimental group and its absence in naturally SIV-infected animals.
对11只自然感染猴免疫缺陷病毒（SIV）的猕猴（其中10只已死亡）的流行病学和临床病理数据，与34只死于实验性感染猴免疫缺陷病毒猕猴（SIVmac）的恒河猴的数据进行了比较。包括受影响的性别、死亡时的年龄以及某些机会性感染的发生等几个差异，可以用实验设计来解释；其他差异仍无法解释。最显著的差异是实验组中脑膜脑脊髓炎的发病率为41%，而自然感染SIV的动物中未出现这种情况。
