Department of Surgical, Medical, and Molecular Pathology and Critical Care, University of Pisa, Pisa, Italy.
Department of Surgical, Medical, and Molecular Pathology and Critical Care, University of Pisa, Pisa, Italy.
Surv Ophthalmol. 2017 Nov-Dec;62(6):828-837. doi: 10.1016/j.survophthal.2017.05.002. Epub 2017 May 12.
The supraciliary space is a physiological route for aqueous humor outflow located anteriorly between the outer surface of the ciliary body and the internal surface of the sclera. Posteriorly, the suprachoroidal space is located between the choroid and the internal surface of the sclera. These spaces have been targeted as suitable and helpful pathways for glaucoma treatment, alternatives to the traditional subconjunctival space. The subconjunctival surgical pathway is affected by several limitations such as poor cosmesis, a lifetime risk for endophthalmitis, and an unpredictable wound healing response. Because of these limitations, the supraciliary space has gained growing interest as a possible target for new glaucoma drainage devices such as: Gold Micro Shunt (SOLX Inc.; Waltham, MA, USA), iStent Supra (Glaukos Corporation, Laguna Hills, CA, USA), CyPass Micro-Stent (Transcend Medical Inc., Menlo Park, CA, USA), Aquashunt (OPKO health Inc., Miami, FL, USA), STARflo (iSTAR Medical, Isnes, Belgium), and Esnoper-Clip implant (AJL Ophthalmics, Álava, Spain). We review the current literature concerning the supraciliary space to evaluate its safety and efficacy as a suitable pathway for glaucoma surgical treatment.
巩膜上腔是房水流出的生理途径，位于睫状体的外表面和巩膜的内表面之间的前部。后部，脉络膜上腔位于脉络膜和巩膜的内表面之间。这些空间已被作为青光眼治疗的合适和有益途径，替代传统的结膜下空间。结膜下手术途径受到多种限制，例如美容效果不佳、终生存在眼内炎风险以及不可预测的伤口愈合反应。由于这些限制，巩膜上腔作为新的青光眼引流装置的潜在目标越来越受到关注，例如：Gold Micro Shunt（SOLX Inc.；马萨诸塞州沃尔瑟姆）、iStent Supra（Glaukos Corporation，加利福尼亚州拉古纳山）、CyPass Micro-Stent（Transcend Medical Inc.，加利福尼亚州门洛帕克）、Aquashunt（OPKO health Inc.，佛罗里达州迈阿密）、STARflo（iSTAR Medical，比利时伊斯诺）和 Esnoper-Clip 植入物（AJL Ophthalmics，阿拉瓦，西班牙）。我们回顾了有关巩膜上腔的当前文献，以评估其作为青光眼手术治疗的合适途径的安全性和有效性。
