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1
A short course of gamma-tocopherol mitigates LPS-induced inflammatory responses in humans ex vivo.短期服用γ-生育三烯酚可减轻体外培养的人体中脂多糖诱导的炎症反应。
J Allergy Clin Immunol. 2017 Oct;140(4):1179-1181.e4. doi: 10.1016/j.jaci.2017.04.030. Epub 2017 May 12.
2
Short course gamma tocopherol did not mitigate effects of ozone on airway inflammation in asthmatics.短期服用γ生育酚不能减轻哮喘患者臭氧对气道炎症的影响。
Inhal Toxicol. 2020 Jun;32(7):279-281. doi: 10.1080/08958378.2020.1800147. Epub 2020 Jul 30.
3
Down-regulation of oxidative DNA lesions in human mononuclear cells after antioxidant supplementation correlates to increase of gamma-tocopherol.抗氧化剂补充后人类单核细胞中氧化性DNA损伤的下调与γ-生育酚的增加相关。
Int J Vitam Nutr Res. 2008 Jul-Sep;78(4-5):183-94. doi: 10.1024/0300-9831.78.45.183.
4
Dietary α- and γ-tocopherol supplementation attenuates lipopolysaccharide-induced oxidative stress and inflammatory-related responses in an obese mouse model of nonalcoholic steatohepatitis.膳食 α-和 γ-生育酚补充可减轻非酒精性脂肪性肝炎肥胖小鼠模型中脂多糖诱导的氧化应激和炎症相关反应。
J Nutr Biochem. 2010 Dec;21(12):1200-6. doi: 10.1016/j.jnutbio.2009.10.006.
5
Nanoemulsions of an anti-oxidant synergy formulation containing gamma tocopherol have enhanced bioavailability and anti-inflammatory properties.含有γ-生育酚的抗氧化协同配方纳米乳剂具有更高的生物利用度和抗炎特性。
Int J Pharm. 2008 Nov 3;363(1-2):206-13. doi: 10.1016/j.ijpharm.2008.07.022. Epub 2008 Jul 31.
6
Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation.
Thromb Res. 2010 Feb;125(2):196-9. doi: 10.1016/j.thromres.2009.11.015. Epub 2009 Dec 8.
7
In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects.在正常人和哮喘患者体内补充γ-生育酚可降低全身氧化应激以及人单核细胞的细胞因子反应。
Free Radic Biol Med. 2008 Jul 1;45(1):40-9. doi: 10.1016/j.freeradbiomed.2008.03.002. Epub 2008 Mar 12.
8
Anti-inflammatory activity in vitro and in vivo of the protein farnesyltransferase inhibitor tipifarnib.蛋白质法尼基转移酶抑制剂替匹法尼在体外和体内的抗炎活性
J Pharmacol Exp Ther. 2006 Apr;317(1):53-60. doi: 10.1124/jpet.105.095976. Epub 2005 Dec 13.
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Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats.γ-生育酚而非α-生育酚可降低大鼠体内促炎性类二十烷酸的水平及炎症损伤。
FASEB J. 2003 May;17(8):816-22. doi: 10.1096/fj.02-0877com.
10
Gamma tocopherol effect on LPS-induced sputum neutrophilia is not modified by BMI or GSTM1 genotype.γ-生育酚对 LPS 诱导的痰中性粒细胞增多的影响不受 BMI 或 GSTM1 基因型的影响。
J Allergy Clin Immunol. 2019 May;143(5):1937-1939. doi: 10.1016/j.jaci.2018.12.1009. Epub 2019 Jan 17.

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1
Balancing the Cellular Inflammatory-Homeostatic Axis Through Natural Ingredient Supplementation.通过补充天然成分平衡细胞炎症-稳态轴
Nutrients. 2025 Aug 8;17(16):2587. doi: 10.3390/nu17162587.
2
The standardization and efficacy of fermented (L.) in combination with enrofloxacin against artificially induced pneumonic pasteurellosis in rat models.发酵（L.）与恩诺沙星联合对大鼠人工诱导的巴氏杆菌肺炎模型的标准化及疗效。
Open Vet J. 2024 Dec;14(12):3404-3416. doi: 10.5455/OVJ.2024.v14.i12.25. Epub 2024 Dec 31.
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A pilot randomized clinical trial of γ-tocopherol supplementation on wood smoke-induced neutrophilic and eosinophilic airway inflammation.一项关于补充γ-生育酚对木烟诱导的中性粒细胞和嗜酸性粒细胞气道炎症影响的先导性随机临床试验。
J Allergy Clin Immunol Glob. 2023 Oct 5;2(4):100177. doi: 10.1016/j.jacig.2023.100177. eCollection 2023 Nov.
4
The Role of Vitamins in the Pathogenesis of Asthma.维生素在哮喘发病机制中的作用。
Int J Mol Sci. 2023 May 10;24(10):8574. doi: 10.3390/ijms24108574.
5
Gamma-tocopherol, a major form of vitamin E in diets: Insights into antioxidant and anti-inflammatory effects, mechanisms, and roles in disease management.γ-生育酚，膳食中维生素 E 的主要形式：抗氧化和抗炎作用、机制以及在疾病管理中的作用的深入了解。
Free Radic Biol Med. 2022 Jan;178:347-359. doi: 10.1016/j.freeradbiomed.2021.12.012. Epub 2021 Dec 9.
6
Metabolism of natural forms of vitamin E and biological actions of vitamin E metabolites.天然形式的维生素 E 的代谢和维生素 E 代谢物的生物学作用。
Free Radic Biol Med. 2022 Feb 1;179:375-387. doi: 10.1016/j.freeradbiomed.2021.11.012. Epub 2021 Nov 14.
7
Asthma, allergy and vitamin E: Current and future perspectives.哮喘、过敏与维生素 E：当前与未来的视角。
Free Radic Biol Med. 2022 Feb 1;179:388-402. doi: 10.1016/j.freeradbiomed.2021.10.037. Epub 2021 Nov 14.
8
The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review.24种营养素和植物营养素对免疫系统功能及炎症的影响：一篇叙述性综述。
J Clin Transl Res. 2021 May 27;7(3):333-376. eCollection 2021 Jun 26.
9
Utilization of redox modulating small molecules that selectively act as pro-oxidants in cancer cells to open a therapeutic window for improving cancer therapy.利用氧化还原调节小分子，这些小分子在癌细胞中选择性地作为促氧化剂发挥作用，为改善癌症治疗打开一个治疗窗口。
Redox Biol. 2021 Jun;42:101864. doi: 10.1016/j.redox.2021.101864. Epub 2021 Jan 16.
10
Short course gamma tocopherol did not mitigate effects of ozone on airway inflammation in asthmatics.短期服用γ生育酚不能减轻哮喘患者臭氧对气道炎症的影响。
Inhal Toxicol. 2020 Jun;32(7):279-281. doi: 10.1080/08958378.2020.1800147. Epub 2020 Jul 30.

本文引用的文献

1
The vitamin E isoforms α-tocopherol and γ-tocopherol have opposite associations with spirometric parameters: the CARDIA study.维生素 E 异构体 α-生育酚和 γ-生育酚与肺量计参数呈相反关联：CARDIA 研究。
Respir Res. 2014 Mar 15;15(1):31. doi: 10.1186/1465-9921-15-31.
2
Supplementation with γ-tocopherol attenuates endotoxin-induced airway neutrophil and mucous cell responses in rats.γ-生育酚补充可减轻内毒素诱导的大鼠气道中性粒细胞和黏液细胞反应。
Free Radic Biol Med. 2014 Mar;68:101-9. doi: 10.1016/j.freeradbiomed.2013.11.024. Epub 2013 Dec 11.
3
Vitamin E, γ-tocopherol, reduces airway neutrophil recruitment after inhaled endotoxin challenge in rats and in healthy volunteers.维生素 E，γ-生育酚，可减少大鼠和健康志愿者吸入内毒素挑战后气道中性粒细胞的募集。
Free Radic Biol Med. 2013 Jul;60:56-62. doi: 10.1016/j.freeradbiomed.2013.02.001. Epub 2013 Feb 9.
4
Natural-source d-α-tocopheryl acetate inhibits oxidant stress and modulates atopic asthma in humans in vivo.天然源 d-α-醋酸生育酚酯抑制氧化应激并调节人类体内特应性哮喘。
Allergy. 2012 May;67(5):676-82. doi: 10.1111/j.1398-9995.2012.02810.x. Epub 2012 Mar 22.
5
Isoforms of vitamin E have opposing immunoregulatory functions during inflammation by regulating leukocyte recruitment.维生素E的异构体在炎症过程中通过调节白细胞募集发挥相反的免疫调节功能。
J Immunol. 2009 Apr 1;182(7):4395-405. doi: 10.4049/jimmunol.0803659.
6
In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects.在正常人和哮喘患者体内补充γ-生育酚可降低全身氧化应激以及人单核细胞的细胞因子反应。
Free Radic Biol Med. 2008 Jul 1;45(1):40-9. doi: 10.1016/j.freeradbiomed.2008.03.002. Epub 2008 Mar 12.
7
Vitamin E chemistry. Nitration of non-alpha-tocopherols: products and mechanistic considerations.维生素E化学。非α-生育酚的硝化作用：产物及机理探讨。
J Org Chem. 2007 Aug 17;72(17):6504-12. doi: 10.1021/jo0706832. Epub 2007 Jul 18.
8
Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality.荟萃分析：补充高剂量维生素E可能会增加全因死亡率。
Ann Intern Med. 2005 Jan 4;142(1):37-46. doi: 10.7326/0003-4819-142-1-200501040-00110. Epub 2004 Nov 10.
9
Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats.γ-生育酚而非α-生育酚可降低大鼠体内促炎性类二十烷酸的水平及炎症损伤。
FASEB J. 2003 May;17(8):816-22. doi: 10.1096/fj.02-0877com.

A short course of gamma-tocopherol mitigates LPS-induced inflammatory responses in humans ex vivo.

作者信息

Burbank Allison J, Duran Charity G, Almond Martha, Wells Heather, Jenkins Sha'Leema, Jiang Qing, Yang Chao, Wang Ting, Zhou Haibo, Hernandez Michelle L, Peden David B

机构信息

Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC; Division of Allergy, Immunology and Rheumatology, Department of Pediatrics, University of North Carolina, Chapel Hill, NC.

Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC.

出版信息

J Allergy Clin Immunol. 2017 Oct;140(4):1179-1181.e4. doi: 10.1016/j.jaci.2017.04.030. Epub 2017 May 12.

DOI:10.1016/j.jaci.2017.04.030
PMID:28506847
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5632577/
Abstract
摘要