Peden David B, Almond Martha, Brooks Christian, Robinette Carole, Wells Heather, Burbank Allison, Hernandez Michelle, Hinderliter Alan, Caughey Melissa, Jiang Qing, Wang Qianyue, Li Haolin, Zhou Haibo, Alexis Neil
Center for Environmental Medicine, Asthma and Lung Biology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
Department of Pediatrics, Division of Allergy and Immunology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC.
J Allergy Clin Immunol Glob. 2023 Oct 5;2(4):100177. doi: 10.1016/j.jacig.2023.100177. eCollection 2023 Nov.
Air pollutants, including particulates from wood smoke, are a significant cause of exacerbation of lung disease. γ-Tocopherol is an anti-inflammatory isoform of vitamin E that has been shown to reduce allergen-, ozone-, and endotoxin-induced inflammation.
The objective of this study was to determine whether γ-tocopherol would prevent experimental wood smoke-induced airway inflammation in humans.
This was a randomized, placebo-controlled clinical trial testing the effect of a short course of γ-tocopherol-enriched supplementation on airway inflammation following a controlled exposure to wood smoke particulates.
Short-course γ-tocopherol intervention did not reduce wood smoke-induced neutrophilic airway inflammation, but it did prevent wood smoke-induced eosinophilic airway inflammation.
γ-Tocopherol is a potential intervention for exacerbation of allergic airway inflammation, but further study examining longer dosing periods is required.
空气污染物，包括木烟中的颗粒物，是导致肺部疾病加重的重要原因。γ-生育酚是维生素E的一种抗炎异构体，已被证明可减轻过敏原、臭氧和内毒素引起的炎症。
本研究的目的是确定γ-生育酚是否能预防实验性木烟引起的人类气道炎症。
这是一项随机、安慰剂对照的临床试验，测试短期补充富含γ-生育酚的制剂对受控暴露于木烟颗粒物后气道炎症的影响。
短期γ-生育酚干预并未减轻木烟引起的嗜中性气道炎症，但确实预防了木烟引起的嗜酸性气道炎症。
γ-生育酚是一种潜在的干预过敏性气道炎症加重的药物，但需要进一步研究更长的给药周期。
