Tamura S, Enjoji M, Toyoshima S, Terasaka R
Second Department of Pathology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Acta Pathol Jpn. 1988 May;38(5):659-65.
We treated a 62-year-old woman with adenomyoepithelioma of the breast, an extremely rare tumor, which showed a bicellular pattern of ductal and myoepithelial elements bearing some histologic resemblance to pleomorphic adenoma of the salivary gland. The tumor was made up of cells positive for actin and S-100 protein, and some positive for epithelial membrane antigen (EMA). Thus, this tumor showed biphasic differentiation towards myoepithelial cells and to duct epithelial cells. Compared with findings in related tumors reported in the literature, the myoepithelial cells in the present tumor were less frequently spindle-shaped and had abundant eosinophilic or clear cytoplasm. A simple mastectomy was done and at the time of writing 20 months later there has been no recurrence. Adjuvant chemotherapy was not prescribed.
我们治疗了一名62岁患有乳腺腺肌上皮瘤的女性，这是一种极其罕见的肿瘤，其显示出导管和肌上皮成分的双细胞模式，在组织学上与涎腺多形性腺瘤有一些相似之处。肿瘤由肌动蛋白和S-100蛋白阳性的细胞组成，一些细胞上皮膜抗原（EMA）呈阳性。因此，该肿瘤显示出向肌上皮细胞和导管上皮细胞的双相分化。与文献报道的相关肿瘤的发现相比，本肿瘤中的肌上皮细胞较少呈梭形，且有丰富的嗜酸性或透明细胞质。实施了单纯乳房切除术，在撰写本文时（20个月后）未出现复发。未进行辅助化疗。
