抗瓜氨酸化蛋白抗体可在多种结缔组织病中检测到。
Anti-carbamylated Protein Antibodies Are Detectable in Various Connective Tissue Diseases.
机构信息
From the Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto; Department of Clinical Immunology and Rheumatology, Wakayama Medical University, Wakayama, Japan.
S. Nakabo, MD, research fellow, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; H. Yoshifuji, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; M. Hashimoto, MD, PhD, Assistant professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; Y. Imura, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; R. Nakashima, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Murakami, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; N. Kuramoto, MD, PhD, Assistant professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; S. Ito, PhD, Assistant professor, Medical Research Support Center, Graduate School of Medicine, Kyoto University; J. Satoh, PhD, Postdoctoral fellow, Medical Research Support Center, Graduate School of Medicine, Kyoto University; M. Tanaka, MD, PhD, Associate professor, Department of the Control for Rheumatic Diseases, Graduate School of Medicine, Kyoto University; T. Fujii, MD, PhD, Professor, Department of Clinical Immunology and Rheumatology, Wakayama Medical University, and Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; T. Mimori, MD, PhD, Professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University; K. Ohmura, MD, PhD, Associate professor, Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University.
出版信息
J Rheumatol. 2017 Sep;44(9):1384-1388. doi: 10.3899/jrheum.161432. Epub 2017 May 15.
OBJECTIVE
Anti-carbamylated protein (anti-CarP) antibodies are possible diagnostic biomarkers of anticitrullinated protein antibody (ACPA)-negative rheumatoid arthritis (RA). We aimed to elucidate the prevalence of anti-CarP antibodies in non-RA connective tissue diseases (CTD) because CTD are important in the differential diagnosis of ACPA-negative RA.
METHODS
The sera from 266 patients with RA and 616 patients with CTD and 80 healthy controls were examined using an in-house anti-CarP ELISA.
RESULTS
The prevalence and the level of anti-CarP antibodies in several CTD were comparable to those in ACPA-negative RA.
CONCLUSION
Anti-CarP antibodies are not useful for differentiating ACPA-negative RA from CTD.
目的
抗氨甲酰化蛋白（anti-CarP）抗体可能是抗瓜氨酸化蛋白抗体（ACPA）阴性类风湿关节炎（RA）的诊断生物标志物。我们旨在阐明抗 CarP 抗体在非 RA 结缔组织疾病（CTD）中的流行情况，因为 CTD 在 ACPA 阴性 RA 的鉴别诊断中很重要。
方法
使用内部抗 CarP ELISA 检测了 266 例 RA 患者、616 例 CTD 患者和 80 例健康对照者的血清。
结果
几种 CTD 的抗 CarP 抗体的患病率和水平与 ACPA 阴性 RA 相当。
结论
抗 CarP 抗体对于区分 ACPA 阴性 RA 与 CTD 没有帮助。
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