Thiriet G, Kempf E, Ebel A
Centre de Neurochimie du CNRS, Strasbourg, France.
Int J Dev Neurosci. 1988;6(3):309-16. doi: 10.1016/0736-5748(88)90011-1.
The response of cholinergic markers to pre- or postsynaptic blockage was followed during development of the chick embryo spinal cord, to understand better the maturation sequence of the developing cholinergic synapse. It has been shown that the developing neurotransmitter system is able to react to pre- or postsynaptic disturbances by compensatory mechanisms, as early as 7.5 days of incubation. From 12.5 days of incubation the synaptic reactivity to such blockage changes in complexity as well as in nature. At this developmental stage muscarinic receptors show capacity for intrinsic regulation, similar to that of the adult nervous system. These results together with our previous studies clearly demonstrate that 12.5-15.5 days of embryonic life appears to be a crucial period in ontogenesis of the cholinergic neurotransmission in the chick embryo spinal cord.
在鸡胚脊髓发育过程中，对胆碱能标志物对突触前或突触后阻断的反应进行了跟踪，以便更好地了解发育中的胆碱能突触的成熟顺序。研究表明，早在孵化7.5天时，发育中的神经递质系统就能通过补偿机制对突触前或突触后的干扰做出反应。从孵化12.5天开始，突触对这种阻断的反应在复杂性和性质上都会发生变化。在这个发育阶段，毒蕈碱受体表现出与成年神经系统相似的内在调节能力。这些结果与我们之前的研究一起清楚地表明，胚胎期12.5 - 15.5天似乎是鸡胚脊髓胆碱能神经传递个体发生过程中的关键时期。
