Shao Hua, Chen Guoming, Zhu Chao, Chen Yongfei, Liu Yamin, He Yuxing, Jin Hui
Department of Pharmacy, Zhongda Hospital, School of Medicine, Southeast University.
Department of Clinical Pharmacy, China Pharmaceutical University.
Patient Prefer Adherence. 2017 May 8;11:897-903. doi: 10.2147/PPA.S92533. eCollection 2017.
In the People's Republic of China, outpatients have limited time with their physicians. Thus, compared to inpatients, outpatients have lower medication adherence and are less knowledgeable about their disease.
The objective of this study was to evaluate the effect of pharmaceutical care on clinical outcomes of outpatients with type 2 diabetes mellitus (T2DM).
A randomized, controlled, prospective clinical trial was conducted recruiting a total of 240 T2DM outpatients from Zhongda Hospital, Southeast University. The control group (CG) received only common care from medical staff, whereas the inter vention group (IG) received extra pharmaceutical care from clinical pharmacists. Biochemical data such as blood pressure (BP), fasting blood glucose (FBG), glycosylated hemoglobin A1 (HbA1c), and blood lipid were collected before and after 6-month intervention. The primary end points in this study were FBG and HbA1c.
After the intervention, most of the baseline clinical outcomes of the patients in IG significantly improved, while only body mass index, diastolic BP, low-density lipoprotein cholesterol, and total cholesterol (TC) improved significantly in patients in the CG. Compared to CG, in IG, there were significant improvements in FBG, HbA1c, TC, the target attainment rates of HbA1c, and BP.
Pharmaceutical care provided by clinical pharmacists could improve the control of diabetes of outpatients, and clinical pharmacists could play an important role in diabetes management.
在中华人民共和国，门诊患者与医生相处的时间有限。因此，与住院患者相比，门诊患者的用药依从性较低，对自身疾病的了解也较少。
本研究的目的是评估药学服务对2型糖尿病（T2DM）门诊患者临床结局的影响。
进行了一项随机、对照、前瞻性临床试验，共招募了来自东南大学附属中大医院的240名T2DM门诊患者。对照组（CG）仅接受医护人员的常规护理，而干预组（IG）接受临床药师提供的额外药学服务。在6个月干预前后收集血压（BP）、空腹血糖（FBG）、糖化血红蛋白A1（HbA1c）和血脂等生化数据。本研究的主要终点是FBG和HbA1c。
干预后，IG组患者的大多数基线临床结局显著改善，而CG组患者仅体重指数、舒张压、低密度脂蛋白胆固醇和总胆固醇（TC）显著改善。与CG组相比，IG组的FBG、HbA1c、TC、HbA1c达标率和血压均有显著改善。
临床药师提供的药学服务可以改善门诊糖尿病患者的病情控制，临床药师在糖尿病管理中可以发挥重要作用。
