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放疗诱导的皮肤反应通过转化生长因子-β1细胞因子介导诱导纤维化。

Radiotherapy-Induced Skin Reactions Induce Fibrosis Mediated by TGF-β1 Cytokine.

作者信息

de Andrade Cherley Borba Vieira, Ramos Isalira Peroba Rezende, de Moraes Alan César Nunes, do Nascimento Ana Lúcia Rosa, Salata Camila, Goldenberg Regina Coeli Dos Santos, de Carvalho Jorge José, de Almeida Carlos Eduardo Veloso

机构信息

Radiological Sciences Laboratory, Department of Biophysics and Biometry, State University of Rio de Janeiro (UERJ), Rio de Janeiro, RJ, Brazil.

Translational Endocrinology Laboratory, Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil.

出版信息

Dose Response. 2017 Apr 28;15(2):1559325817705019. doi: 10.1177/1559325817705019. eCollection 2017 Apr-Jun.

DOI:10.1177/1559325817705019
PMID:28507463
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5415163/
Abstract

PURPOSE

This study aimed to investigate radiation-induced lesions on the skin in an experimental animal model. Cutaneous wounds were induced in Wistar rats by 4 MeV energy electron beam irradiation, using a dose rate of 240 cGy/min, for 3 different doses (10 Gy, 40 Gy, and 60 Gy). The skin was observed 5, 10, and 25 days (D) after ionizing radiation exposition.

RESULTS

Infiltrate inflammatory process was observed in D5 and D10, for the 40 Gy and 60 Gy groups, and a progressive increase of transforming growth factor β1 is associated with this process. It could also be noted a mischaracterization of collagen fibers at the high-dose groups.

CONCLUSION

It was observed that the lesions caused by ionizing radiation in rats were very similar to radiodermatitis in patients under radiotherapy treatment.

ADVANCES IN KNOWLEDGE

This study is important to develop strategies to prevent radiation-induced skin reactions.

摘要

目的

本研究旨在通过实验动物模型研究辐射对皮肤造成的损伤。使用能量为4兆电子伏特的电子束，剂量率为240厘戈瑞/分钟，对Wistar大鼠进行照射，设置3种不同剂量（10戈瑞、40戈瑞和60戈瑞）以造成皮肤创伤。在电离辐射暴露后第5、10和25天对皮肤进行观察。

结果

在第5天和第10天，40戈瑞和60戈瑞组观察到炎性浸润过程，转化生长因子β1的逐渐增加与该过程相关。在高剂量组还可注意到胶原纤维的特征改变。

结论

观察到电离辐射在大鼠身上造成的损伤与接受放射治疗患者的放射性皮炎非常相似。

知识进展

本研究对于制定预防辐射引起的皮肤反应的策略具有重要意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5721/5415163/09202b6eb566/10.1177_1559325817705019-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5721/5415163/9421f3e8daa8/10.1177_1559325817705019-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5721/5415163/e9dcfcc3375b/10.1177_1559325817705019-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5721/5415163/0aede0335add/10.1177_1559325817705019-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5721/5415163/4b888e05f5dd/10.1177_1559325817705019-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5721/5415163/09202b6eb566/10.1177_1559325817705019-fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5721/5415163/9421f3e8daa8/10.1177_1559325817705019-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5721/5415163/e9dcfcc3375b/10.1177_1559325817705019-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5721/5415163/0aede0335add/10.1177_1559325817705019-fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5721/5415163/4b888e05f5dd/10.1177_1559325817705019-fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5721/5415163/09202b6eb566/10.1177_1559325817705019-fig5.jpg

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