Hernandez-Torres Francisco, Rodríguez-Outeiriño Lara, Franco Diego, Aranega Amelia E
Cardiac and Skeletal Myogenesis Group, Departmento de Biología Experimental, Universidad de JaénJaén, Spain.
Cardiac and Skeletal Myogenesis Group, Fundación MEDINA Centro de Excelencia en Investigación de Medicamentos Innovadores en AndalucíaGranada, Spain.
Front Cell Dev Biol. 2017 May 1;5:46. doi: 10.3389/fcell.2017.00046. eCollection 2017.
Skeletal muscle is a heterogeneous tissue that represents between 30 and 38% of the human body mass and has important functions in the organism, such as maintaining posture, locomotor impulse, or pulmonary ventilation. The genesis of skeletal muscle during embryonic development is a process controlled by an elaborate regulatory network combining the interplay of extrinsic and intrinsic regulatory mechanisms that transform myogenic precursor cells into functional muscle fibers through a finely tuned differentiation program. However, the capacity of generating muscle still remains once these fibers have matured. Adult myogenesis resembles many of the embryonic morphogenetic episodes and depends on the activation of satellite cells that have the potential to differentiate into new muscle fibers. is a member of the family of homeodomain transcription factors that play an important role in morphogenesis. In the last decade, has emerged as a key element involved in the fine-tuning mechanism that regulates skeletal-muscle development as well as the differentiation and cell fate of satellite cells in adult muscle. Here we present an integrative view of all aspects of embryonic and adult myogenesis in which is involved, from embryonic development to satellite-cell proliferation, fate specification, and differentiation. Those new functions on satellite-cell biology might open new perspectives to develop therapeutic strategies for muscular disorders.
骨骼肌是一种异质性组织，占人体体重的30%至38%，在机体中具有重要功能，如维持姿势、运动冲动或肺通气。胚胎发育过程中骨骼肌的发生是一个由精细调控网络控制的过程，该网络结合了外在和内在调控机制的相互作用，通过精细调节的分化程序将成肌前体细胞转化为功能性肌纤维。然而，一旦这些纤维成熟，产生肌肉的能力仍然存在。成体肌生成类似于许多胚胎形态发生过程，依赖于具有分化为新肌纤维潜力的卫星细胞的激活。 是同源域转录因子家族的成员，在形态发生中起重要作用。在过去十年中， 已成为参与精细调节机制的关键元素，该机制调节骨骼肌发育以及成体肌肉中卫星细胞的分化和细胞命运。在这里，我们展示了涉及 的胚胎和成体肌生成所有方面的综合观点，从胚胎发育到卫星细胞增殖、命运决定和分化。 对卫星细胞生物学的这些新功能可能为开发肌肉疾病的治疗策略开辟新的前景。
