Sarkisova K Yu, Gabova A V, Kulikov M A, Fedosova E A, Shatskova A B, Morosov A A
Institute of Higher Nervous Activity and Neurophysiology RAS, Moscow, Russia.
Institute of Radio Engineering and Radioelectronics RAS, Moscow, Russia.
Dokl Biol Sci. 2017 Mar;473(1):39-42. doi: 10.1134/S0012496617020077. Epub 2017 May 16.
It has been shown for the first time that rearing by a foster Wistar mother with high level of maternal care (MC) counteracts the expression of genetic absence epilepsy (AE) and comorbid depression - reduces the number, duration and index of spike-wave discharges (SWDs) and immobility time in the forced swimming test, as well as exerts substantial effects on morphology and time-frequency dynamics of SWDs in WAG/Rij rats. It is supposed that increases in MC early in development might be used to counteract epileptogenesis and comorbid depression in people genetically predisposed to AE.
首次表明，由具有高水平母性关怀（MC）的寄养Wistar母亲抚养，可以抵消遗传性失神癫痫（AE）和共病抑郁症的表现——减少棘波放电（SWD）的数量、持续时间和指数以及强迫游泳试验中的不动时间，并且对WAG/Rij大鼠SWD的形态和时频动态产生显著影响。据推测，发育早期母性关怀的增加可能用于抵消有AE遗传倾向人群的癫痫发生和共病抑郁症。
