健康与疾病中的瞬时受体电位通道

TRPC Channels in Health and Disease.

作者信息

Tai Yilin, Yang Shenglian, Liu Yong, Shao Wei

机构信息

Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY, 11724, USA.

Center of Cognition and Brain Science, Institute of Basic Medical Science, Beijing, 100039, China.

出版信息

Adv Exp Med Biol. 2017;976:35-45. doi: 10.1007/978-94-024-1088-4_4.

DOI:10.1007/978-94-024-1088-4_4

PMID:28508311

Abstract

This chapter offers a brief introduction of the functions of TRPC channels in non-neuronal systems. We focus on three major organs of which the research on TRPC channels have been most focused on: kidney, heart, and lung. The chapter highlights on cellular functions and signaling pathways mediated by TRPC channels. It also summarizes several inherited diseases in humans that are related to or caused by TRPC channel mutations and malfunction. A better understanding of TRPC channels functions and the importance of TRPC channels in health and disease should lead to new insights and discovery of new therapeutic approaches for intractable disease.

摘要

本章简要介绍了瞬时受体电位经典型（TRPC）通道在非神经元系统中的功能。我们重点关注TRPC通道研究最为集中的三个主要器官：肾脏、心脏和肺。本章突出了TRPC通道介导的细胞功能和信号通路。它还总结了人类中几种与TRPC通道突变和功能障碍相关或由其引起的遗传性疾病。更好地理解TRPC通道的功能以及TRPC通道在健康和疾病中的重要性，应该会带来新的见解，并发现针对难治性疾病的新治疗方法。