瞬时受体电位通道下游信号级联反应

TRPC Channel Downstream Signaling Cascades.

作者信息

He Zhuohao

机构信息

Department of Pathology and Laboratory Medicine, Institute on Aging and Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA.

出版信息

Adv Exp Med Biol. 2017;976:25-33. doi: 10.1007/978-94-024-1088-4_3.

DOI:10.1007/978-94-024-1088-4_3

PMID:28508310

Abstract

The family of TRP channel is comprised of a large group of cation-permeable channels, displaying as signaling integrators for sensing extracellular stimulus and initiating intracellular signaling cascades. This chapter offers a brief review of the signaling molecules related to TRPC channels, the first identified mammalian TRP family. Besides the signaling molecules involved in TRPC activation, I will focus on their upstream and downstream signaling cascades and the molecules involved in their intracellular trafficking.

摘要

瞬时受体电位（TRP）通道家族由一大类阳离子通透通道组成，作为信号整合器，用于感知细胞外刺激并启动细胞内信号级联反应。本章简要综述与TRPC通道相关的信号分子，TRPC通道是最早被鉴定的哺乳动物TRP家族。除了参与TRPC激活的信号分子外，我将重点关注它们的上游和下游信号级联反应以及参与其细胞内运输的分子。