在黑暗来临之前进行β-肾上腺素能刺激可提前叙利亚仓鼠松果体褪黑素合成的夜间增加。
Beta-adrenergic stimulation prior to darkness advances the nocturnal increase of Syrian hamster pineal melatonin synthesis.
作者信息
Gonzalez-Brito A, Reiter R J, Santana C, Menendez-Pelaez A, Guerrero J M
机构信息
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio 78284.
出版信息
Brain Res. 1988 Dec 20;475(2):393-6. doi: 10.1016/0006-8993(88)90633-6.
Pineal glands of male Syrian hamsters stimulated in vivo with isoproterenol (ISO) for 4 h before the onset of darkness showed a 4-h advance in the timing of the nighttime increases in both N-acetyltransferase activity and melatonin levels. When ISO (1 mg/kg) was administered every 2 h to animals kept in light during the night, a significant increase in melatonin synthesis was observed after 4-6 h. The results suggest that the Syrian hamster pineal gland can respond in vivo to continuous beta-adrenergic stimulation, but a lag period of 4-6 h is required before there is an increase in melatonin synthesis.
在黑暗开始前4小时用异丙肾上腺素（ISO）对雄性叙利亚仓鼠进行体内刺激，其松果体在夜间N - 乙酰转移酶活性和褪黑素水平增加的时间上提前了4小时。当在夜间光照条件下每2小时给动物注射ISO（1毫克/千克）时，4 - 6小时后观察到褪黑素合成显著增加。结果表明，叙利亚仓鼠松果体在体内可对持续的β - 肾上腺素能刺激作出反应，但在褪黑素合成增加之前需要4 - 6小时的延迟期。
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