Kwon Dong Hyang, Johnson Lynt B, Ozdemirli Metin
1 Georgetown University Hospital, Washington, DC, USA.
Int J Surg Pathol. 2017 Oct;25(7):619-622. doi: 10.1177/1066896917710717. Epub 2017 May 16.
Choledochal cyst is a cystic dilation of the biliary tree that can increase the risk of malignancy in bile ducts and the gallbladder. These are usually lined by bile duct epithelium, which may undergo intestinal and squamous metaplasia. This is the first report of clinically diagnosed type II choledochal cyst that is entirely lined by metaplastic stratified squamous epithelium, unlike most other cysts, which are histologically lined by bile duct epithelium. This observation can potentially explain the underlying pathogenic mechanism of rare reports of squamous cell carcinomas arising in bile duct systems.
胆总管囊肿是胆管树的囊性扩张，可增加胆管和胆囊发生恶性肿瘤的风险。这些囊肿通常内衬胆管上皮，胆管上皮可能会发生肠化生和鳞状化生。这是首例临床诊断为II型胆总管囊肿的报告，该囊肿完全由化生的复层鳞状上皮内衬，与大多数其他囊肿不同，后者在组织学上由胆管上皮内衬。这一观察结果可能有助于解释胆管系统中罕见的鳞状细胞癌报告的潜在致病机制。
