College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, Kyungpook National University, 80 Daehak-ro, Buk-gu, Daegu, 41566, Republic of Korea.
Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, 38610, Republic of Korea.
Arch Pharm Res. 2018 Mar;41(3):276-287. doi: 10.1007/s12272-017-0919-9. Epub 2017 May 16.
Zingerone (ZGR), a phenolic alkanone isolated from ginger, has been reported to possess various pharmacological activities. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGF-β. TGFBIp is released by human umbilical vein endothelial cells and functions as a mediator of experimental sepsis. We hypothesized that ZGR could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here, we investigated the anti-septic effects and underlying mechanisms of ZGR against TGFBIp-mediated septic responses. ZGR effectively inhibited lipopolysaccharide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, ZGR suppressed TGFBIp-induced sepsis lethality and pulmonary injury. In conclusion, ZGR suppressed TGFBIp-mediated and CLP-induced septic responses. Therefore, ZGR could be a potential therapeutic agent for treatment of various severe vascular inflammatory diseases via inhibition of the TGFBIp signaling pathway.
姜酮（ZGR）是从生姜中分离出来的一种酚烷酮，据报道具有多种药理活性。转化生长因子-β诱导蛋白（TGFBIp）是一种细胞外基质蛋白，其在几种细胞类型中的表达被 TGF-β 大大增加。TGFBIp 由人脐静脉内皮细胞释放，并作为实验性败血症的介质发挥作用。我们假设 ZGR 可以减少 TGFBIp 介导的人内皮细胞和小鼠的严重炎症反应。在这里，我们研究了 ZGR 对 TGFBIp 介导的败血症反应的抗败血症作用及其潜在机制。ZGR 有效抑制脂多糖诱导的 TGFBIp 释放，并抑制 TGFBIp 介导的败血症反应。此外，ZGR 抑制了 TGFBIp 诱导的败血症致死率和肺损伤。总之，ZGR 抑制了 TGFBIp 介导和 CLP 诱导的败血症反应。因此，ZGR 可能通过抑制 TGFBIp 信号通路成为治疗各种严重血管炎症疾病的潜在治疗剂。
