Oshiro Yoshiyuki, Tanaka Hisataka, Kawasaki Fumiko, Okimoto Niro
Department of General Internal Medicine 1, Kawasaki Medical School, Kawasaki Hospital, 2-1-80 Nakasange, Kita-ku, Okayama, 700-8505, Japan.
CEN Case Rep. 2016 Nov;5(2):219-222. doi: 10.1007/s13730-016-0228-z. Epub 2016 Jul 16.
It has been noted that cyclosporine A (CsA) is an effective drug for membranous nephropathy (MN). Diabetes is a common disease that sometimes causes nephrotic syndrome. We report the case of an 89-year-old woman with type 2 diabetes mellitus who exhibited nephrotic syndrome. Examination of a renal biopsy indicated MN and she was prescribed CsA as monotherapy. Her edema subsided and she achieved partial remission. This is the first report of a patient in diabetic condition with MN having achieved partial remission after CsA monotherapy without steroid therapy. The use of steroid in patients with diabetes may worsen their diabetic condition, especially if they are of very advanced age. CsA monotherapy may be useful for diabetic patients with MN.
已经注意到环孢素A（CsA）是治疗膜性肾病（MN）的有效药物。糖尿病是一种常见疾病，有时会导致肾病综合征。我们报告了一例89岁2型糖尿病女性患者出现肾病综合征的病例。肾活检检查显示为MN，她被给予CsA单一疗法。她的水肿消退，病情实现部分缓解。这是首例糖尿病合并MN患者在未接受类固醇治疗的情况下，仅使用CsA单一疗法后实现部分缓解的报告。糖尿病患者使用类固醇可能会使他们的糖尿病病情恶化，尤其是对于年龄非常大的患者。CsA单一疗法可能对糖尿病合并MN的患者有用。
