一例伴有系膜IgA沉积的抗肾小球基底膜肾小球肾炎病例报告。
A case report of the anti-glomerular basement membrane glomerulonephritis with mesangial IgA deposition.
作者信息
Yamaguchi Hiroshi, Takizawa Hideki, Ogawa Yayoi, Takada Tamaki, Yamaji Izumi, Ura Nobuyuki
机构信息
Department of Nephrology, Teine Keijinkai Hospital, 1-12-1-40 Maeda, Teine-ku, Sapporo, Hokkaido, 006-8555, Japan.
Hokkaido Renal Pathology Center, Sapporo, Hokkaido, Japan.
出版信息
CEN Case Rep. 2013 May;2(1):6-10. doi: 10.1007/s13730-012-0029-y. Epub 2012 Aug 2.
A 46-year-old Japanese male with a past medical history of microscopic hematuria presented with nausea, vomiting, and abdominal pain for which he had been diagnosed with rapidly progressive glomerulonephritis with a peak serum creatinine of 6.6 mg/dL and anti-glomerular basement membrane antibody of 214 EU. Light microscopy showed cellular crescent formation, and immunofluorescence illustrated both linear staining of IgG along the glomerular basement membrane and granular staining of IgA and C3 in the mesangial area; however, the PAS staining of mesangial expansions and mesangial proliferations were not observed. Clinical and histological findings suggested anti-glomerular basement membrane glomerulonephritis with mesangial IgA deposition, suggesting IgA nephropathy, a rare condition.
一名46岁的日本男性，既往有镜下血尿病史，此次因恶心、呕吐和腹痛就诊，被诊断为快速进展性肾小球肾炎，血清肌酐峰值为6.6mg/dL，抗肾小球基底膜抗体为214EU。光镜显示细胞性新月体形成，免疫荧光显示IgG沿肾小球基底膜呈线性染色，IgA和C3在系膜区呈颗粒状染色；然而，未观察到系膜扩张和系膜增生的PAS染色。临床和组织学表现提示为伴有系膜IgA沉积的抗肾小球基底膜肾小球肾炎，提示为IgA肾病，这是一种罕见的疾病。
Zotero 插件