Sánchez-Chapula J
Centro Universitario de Investigaciones Biomédicas, Universidad de Colima, México.
Eur J Pharmacol. 1988 Nov 8;156(3):303-8. doi: 10.1016/0014-2999(88)90274-9.
The effects of bupivacaine on the membrane currents of single guinea-pig ventricular myocytes were investigated using the whole-cell patch-clamp technique. Bupivacaine decreased the inward calcium current in a concentration-dependent way at concentrations of 10 microM and higher. Bupivacaine also decreased the delayed outward current without modifying the inward-rectifying potassium current. From these results it can be concluded that bupivacaine, at concentrations lower than 10 microM, does not exert its negative inotropic effect by decreasing the calcium current. This mechanism may play a role at higher concentrations of the drug.
采用全细胞膜片钳技术研究了布比卡因对单个豚鼠心室肌细胞膜电流的影响。布比卡因在浓度为10微摩尔及以上时，以浓度依赖性方式降低内向钙电流。布比卡因还降低延迟外向电流，而不改变内向整流钾电流。从这些结果可以得出结论，浓度低于10微摩尔的布比卡因不会通过降低钙电流发挥其负性肌力作用。该机制可能在药物浓度较高时起作用。
